Lecture #17 - Nuclear receptors

Question 1

1. Why are nuclear receptors important? (2)
2. Testosterone and Oestrogen - do both M and F have these?
3. When is cortisol released? How does it relate to inflammation? What does this do to immune system?

Answer 1

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Question 2

1. Where are nuclear receptors found? Where can it also be found?

Answer 2

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Question 3

What happens when an agonist binds to nuclear receptor? (7)

Answer 3

1. Drug-receptor complex
2. Dimer
3. Dimer moves to nucleus
4. Binds to DNA (hormone response element)
5. Initiates transcription
6. Synthesis of new proteins
7. Alters the physiology/biochemistry

Question 4

1. What is a nuclear receptor also called?
2. Where do you find it?
3. Effector?
4. Coupling?
5. Response time?
6. Example of receptor?

Answer 4

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Question 5

1. Example of an agonist?
2. What receptor does it activate? (it’s a nuclear receptor but what’s the name?)
3. What’s the clinical use of this agonist’s modified compounds?
4. What about the adverse drug effects?
5. Non-clinical use of the modified compounds?

Answer 5

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Question 6

What are the 7 steps involved in mechanisms of action of testosterone?

Answer 6

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Question 7

What is the rationale for development of the hormonal male contraceptives? (3)

Answer 7

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Question 8

How does testosterone induce infertility?

Answer 8

It’s important for spermatogenesis

But it also negatively feedback on the hypo and ant pit to stop production

So if we increase testosterone then it’ll negatively feedback and stop production of testosterone so sperm making stopped