Lecture #15 - Ligand-gated ion channels

Question 1

What is pharmacology?

Answer 1

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Question 2

What is toxicology?

Answer 2

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Question 3

What is a drug and where is it used? (5)

Answer 3

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Question 4

1. How do drugs act?
2. What is a receptor?
3. What is this theory called?
4. What are 4 examples of receptor

Answer 4

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Question 5

What is the receptor theory? Three steps

Answer 5

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Question 6

What is an agonist and what is an antagonist?

Answer 6

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Question 7

What are ligand-gated ion channels also called?

Answer 7

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Question 8

What are ligand-gated ion channels important?

Answer 8

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Question 9

What are ligand-gated ion channels?
A ____ found in….

How many proteins?

Answer 9

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Question 10

Once an agnostic binds…..(3)

Answer 10

….to the receptor, receptor goes under a conform change (1) and then ions flow through (2) and then they change the the physiology of the cell

Question 11

Ligand-gated ion channels:

1. Also called?
2. Location?
3. Effector?
4. Coupling?
5. Response time? Why?
6. What is ion specificity determined by?
7. Influx of Na+ leads to what and Cl- leads to what?
8. An example of a ligand-gated ion channel and its drug is?

Answer 11

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Question 12

What two things bind to nicotinic receptors (ligand-gated ion channels)? And where do you find both?

Answer 12

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Question 13

How is nicotine from the smoke absorbed vs nicotine from the gum?

Answer 13

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