Lecture 16 Flashcards
Where does molecules get exchanged at the capillary?
At the interstitial fluid
How are large proteins transported at the capillary?
By vascular transport or transcytosis
What are the movement types in bulk flow?
Blood hydrostatic pressure - fluid out of arterial end
Blood osmotic pressure - pressure against capillary from ISF (plasma)
Interstitial fluid pressure (hydrostatic/ osmotic) - pushes for reabsorption of molecules in or out of capillary
What is the sum of hydrostatic and osmotic pressure on the capillary called?
The net filtration pressure
NFP = (BHP + IFOP) - (BOP + IFHP)
How much fluid is reabsorbed after the capillary exchange center?
90% is reabsorbed and 10% is collected by the lymphatic vessels
Why does excess edema occur?
An accumulation of fluid (swelling) due to:
High BP
Protein leakage from vessels
Low plasma protein
Obstructive lymphatic vessels (cannot absorb)
How does circulatory shock occur?
From poor blood flow causing cells to not receive nutrients or O2
What are the 2 types of circulatory shocks?
Hypovolemic shock - loss of blood volume => diarrhea and vomiting
Vascular shock - blood volume normal but vessels are too expanded (allergy)
What are the types of vascular shocks?
Anaphylactic - allergic reaction that releases histamine
Septic - bacterial infection with toxins
Cardiogenic - heart failure decreases CO/ low BP
What are the different shock stages? ( compensated, progressive, irreversible shock)
The progression of circulatory shock from elevated HR to cell death
What is blood composed of?
Plasma
Elements (platelets and cells)
What is blood plasma composed of?
Liquid extracellular matrix and makes 55% of blood volume
91% water
Where are plasma proteins made?
In liver cells (hepatocytes)
What are plasma proteins composed of?
Albumins - main blood volume and pressure regulator made form liver and brings water to blood
Globulins - alpha beta and gamma
Fibrinogen - made into clotting fibers
What is the role of plasma proteins?
PH buffers
