Lecture 14 Flashcards
1
Q
How does the activation of T cells by DCs occur?
A
1.Signal (TCR activation) and signal 2 (costimulation) induce IL-2 production
2. IL-2 acts on T cells to support T cells expansion in both autocrine (mostly) and paracrine manners
2
Q
What kind of affinity do Naive T cells have to IL-2?
A
Low affinity
3
Q
What kind of affinity do activated T cells have to IL-2 receptor
A
High affinity
-Activated T cells have IL-2receptor alpha chain which gives high affinity to IL-2 receptor
4
Q
Autocrine
A
Immune cells secretes a cytokine that binds to its receptors on that same cell
5
Q
Paracrine
A
Immune cell secretes cytokine to induce changes in nearby cells
