Lecture 12

Question 1

What kind of cells survive irradiation?

Answer 1

Cells that do not divide rapidly, such as epithelial cells

Question 2

Which cells are deleted due to irradiation?

Answer 2

Cells that do divide rapidly, such as hematopoietic cells

Question 3

To be a bone marrow donor the recipient and donor must share at least partially what?

Answer 3

MHC I and II alleles

Question 4

What will happen to a patient who received bone marrow of completely different HLA type?

Answer 4

If HLA does not match–>no immune response

Question 5

What will happen if a patient who received bone marrow sharing some HLA class I and II allotypes?

Answer 5

Same HLA haplotype on donor & recipient–>infection is eliminated

Question 6

Are hematopoietic cells radiation sensitive or resistant? And where are they derived from?

Answer 6

-Radiation sensitive
-derived from donor

Question 7

Are Stroma cells radiation sensitive or radiation resistant? And where are they derived from?

Answer 7

-Radiation resistant
-Derived from T cells

Question 8

What kind of cells express positive selection?

Answer 8

cTEC
-cortical epithelium cells

Question 9

What kind of cells express Negative Selection?

Answer 9

mTEC & mDC
-medullary epithelium cells
-medullary dendritic cells

Question 10

If there is no interaction between the TCR and MHC what happens?

Answer 10

Death by neglect

Question 11

What happens if a TCR binds w/ low affinity to MHC?

Answer 11

Positive Selection
-survival and maturation

Question 12

What happens if a TCR binds w/ high affinity to MHC

Answer 12

Negative Selection
-DEATH