Lecture 13 - Heart disease, hypertension, stroke and diabetes Flashcards
what is Cardiovascular Disease (CVD)
CVD = disease anywhere within the cardiovascular system (i.e. the heart blood vessels, and veins)
what are the different types of CVD
Coronary Heart Disease
Atherosclerosis in Coronary Arteries
Coronary Heart Disease: What is it?
General term referring to illnesses caused by atherosclerosis
ì narrows or blocks the coronary arteries (vessels that supply heart with blood)
what can Heart Disease lead to
ì Angina pectoris ì Heart attack
Stroke
explain the CHD: Role of Stress
Exposure to chronic stress
In the worry and strain of modern life arterial degeneration is not
only very common, but develops often at a relatively early age. For this I believe that the high pressure at which men live, and the habits of working the machine to its maximum capacity, are responsible, rather than excesses in eating or drinking. Sir William Osler, 1901
Anger, particularly cynical hostility, is most related to CHD
Atherosclerosis and Stress: Possible Mechanism 1
Cardiovascular Reactivity to Stress
• Responsiveness of the cardiovascular system to stress
• Differs between people
• Stronger stress reactions –> contribute to inflammatory
processes leading to atherosclerosis
Atherosclerosis and Stress - Possible Mechanism 2:
The Role of Systolic BP Reactivity
Atherosclerosis and Stress: Possible Mechanism 3
Personality: Hostility, in particular cynical hostility, most related to higher inflammation in the arteries and thus CHD
• Higher levels of pro-inflammatory cytokines
CHD: Associations
Negative Emotions ì Strong associations between ì Depression and heart attack ì Hopelessness and heart attack ì Anxiety and sudden cardiac death
Assumed to be due to direct and indirect effects.
Other (Related) Risk Factors for CHD
ì Cigarette smoking ì Diabetes ì Hypertension ì Obesity ì Physical inactivity ì Metabolic syndrome Obesity centered around the waist, high levels of triglycerides and low levels of HDL cholesterol. and difficulty metabolizing blood sugar
High Blood Pressure: Behavioural Influences
Sodium consumption • Increases water retention and blood volume • Sodium reactivity • Stress • Obesity
what is Nocturnal Dipping
blood pressure lowers at night
why is lack of nocturnal BP dipping an issue
higher cardiovascular mortality
Non-dipper:
• BP drops less than 10% at night
Correlates with sleep quality, age, stress
what is the Treatment of Hypertension
Serious Hypertension: Medications
• Reduce blood volume (Diuretics)
• Reduce sympathetic activity (cardiac output)
• Beta-blocking agents are used in cardiac rehabilitation to
resist the effects of sympathetic nervous system stimulation
Meditation
what happens if poor adherence for hypertension
• Long term treatment (life-long) • Few symptoms