Lecture 13 Flashcards
What is a pro-inflammatory cytokine?
IL-1
What are the effects of the pro-inflammatory cytokines?
Promote inflammatory processes, Limit tissue damage, initiate immune mechanisms, body temperature, sleep patterns
What is IL-4?
An adaptive response cytokine which causes B cells to produce antibodies
What is interferon-gamma?
An adaptive response cytokine which causes T cells to produce cytotoxic cells
What is the long name for chemokines?
Chemotatic Cytokines
What is an example of a chemotatic cytokine and what is its function?
IL-8 Which attracts neutrophils
What is a haematopoietic cytokine?
GM-CSF, Which stimulates the production of neutrophils
What immune cell is most responsible for regulation of the immmune response via cytokines?
CD4 T Cells/Helper T cells
What is the difference between selectins and integrins?
Selectins perform weak, transient interactions and encourage neutrophil rolling
Integrins result in strong cell to cell interactions promoting migration of the neutrophil
What is the function of co-stimulator molecules?
Modulate what happens after a correct specific T cell is found for a presented antigen
What are the two signals received by a lymphocyte with regards to antigen recognition?
- Recognition of the antigen presented
2. Recognition of the costimulator molecule
What is the consequence of a lymphocyte experiencing only the first recognition signal?
The cell will become anergic or inactive and then slowly die
What happens if both signals are received by the lymphocyte?
An immune response is mounted
What cell in the lymphocyte/APC interaction controls if the second signal is recieved?
The APC as the co-stimulator molecule generating the will only be expressed if the processed antigen is considered dangerous
