Lecture 12 Flashcards

1
Q

Where is phosphorus found in the body?

A

80-85% is in the skeleton. The remainder is found in either soft tissue or in fluids.

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2
Q

Where is phosphorous absorbed from and what is the uptake driven by?

A

Phosphorous is absorbed within the small intestine it’s uptake is driven by Vitamin D/calcitriol.

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3
Q

What are good dietary sources of phosphorous?

A
  • milk
  • cereal grains
  • animal by-products
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4
Q

What are poor dietary sources of phosphorous?

A
  • hays and straws
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5
Q

How available is phytates phosphorus?

A

Phytates phosphorous is very poorly available

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6
Q

What are the general deficiency signs that are observed with phosphorous?

A

Generally same as the calcium deficiency signs and also pica (a depraved appetite)

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7
Q

What are the clinical signs associated with an excess of phosphorous and Mg?

A

bladder stones/urinary crystals are often observed

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8
Q

Where is magnesium found within the body?

A
70% in skeleton 
25% in muscles 
4% in cells
1% in extracellular space 
all have important roles in enzyme activation
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9
Q

What dietary factors lead to a decrease in absorption of magnesium?

A
  1. Absorption is decreased by high potassium
  2. Absorption is decreased by high Ca and P
  3. Absorption is decreased by oxalates and phytates
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10
Q

What are some good dietary sources of magnesium?

A

good sources: cereal bran, dried yeast, milk

variable: grasses and forage crops

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11
Q

What are the common clinical signs of a magnesium deficiency?

A
  1. Anorexia and reduced weight gain

2. Hypomagnesaemic tetany

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12
Q

How is hypomagnesemia treated?

A

Treated with the use of magnesium salts, these are often combined with Ca salts.

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13
Q

What are the risk factors for hypomagesemia?

A
  1. High K
  2. Low Na
  3. Low Na:K
  4. High crude protein
  5. Low Fermentable CHO
  6. Low NDF/short rumen transit time
  7. High lipid/fatty acids
  8. No Mg supplement
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14
Q

How can Mg be supplemented in the diet?

A
  1. With the use of magnesium oxide or magnesium sulfate

2. Use of Mg-rich fertiliser on pasture

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15
Q

What are the vitamers for Vitamin A?

A

Retinoids

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16
Q

What sources can Vitamin A be derived from?

A

Pre-formed vitamin A = animal tissues and animal products
Pro-Vitamin A (carotenoids) = = plants
Synthetic vitamin A = supplements

17
Q

How many molecules of Vitamin A can be made for one molecule of B-carotene?

A

1 molecule of B-carotene = 2 molecules of Vitamin A

18
Q

What are the functions of Vitamin A?

A
  1. Vision
  2. Epithelial cell differentiation
  3. Growth
  4. Reproduction
  5. Immune response and healing
19
Q

What is the effects of chronic Vitamin A toxicity?

A
  1. Anorexia, weight loss
  2. Skin thickening, scaly dermatitis
  3. Deforming cervical spondylosis in cats
20
Q

Where is Vitamin K found?

A

Vitamin K1 = fresh, green, leafy plants
Vitamin K2 = Bacteria in the GIT
Vitamin K3 = supplements

21
Q

What is the function of Vitamin K?

A

coagulation

22
Q

When do Vitamin K deficiencies occur?

A
  1. Extended use of antibiotics
  2. prevention of coprophagy
  3. Pancreatic insufficiency and fat malabsorption
  4. Genetic abnormality
  5. Vitamin E supplements
23
Q

What are common Vitamin K antagonists and inhibitors?

A
  1. Dicoumarol - Vitamin K antagonist
  2. Mycotoxins - Aspergillum in weather damaged hay
  3. Warfarin
  4. Vitamin E
24
Q

Evaluate the possibility of Vitamin K toxicity:

A

1000 times dietary daily needed for toxicity.