Lecture 10 week 6 Flashcards

1
Q

What is the role of hormones?

A

Modulates:
* Growth & development
* Homeostasis
* Reproduction
* Many other roles in the CCN e.g. neurodevelopment & immunity

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2
Q

What are the three origins of hormones

A
  1. Endocrine glands
  2. Nerves
  3. Organs (produce
    hormones as a secondary function)
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3
Q

What two systems interact to form the foundation of the CCN?

A

Nervous and endocrine system

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3
Q

What are all primary endocrine glands and secondary endocrine tissues supplied neurons by?

A

By neurons of the autonomic nervous system

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3
Q

Where can some nerves release their neurotransimitters directly into and what are they called?

A

Directly into the bloodstream and they are called neurohormones

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4
Q

What can neurotransmitters modulate? Give an example.

A

Can modulate hormone secretion.

ex. norepinephrine increases epinephrine and decreases insulin

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5
Q

What do neurons in the CNS and PNS have? Give some examples

A

They have receptors for many hormones.
ex. insulin, estrogen, testosterone, etc

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6
Q

What are neurotransmitters?

A

Chemical messengers released by nerve cells (neurons)

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7
Q

What are neurohormones?

A

Neurotransmitters that are released into the bloodstream by neurons

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8
Q

How do neurotransmitters travel?

A

Transmit signals to adjacent cells, typically within nervous system

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9
Q

How do neurohormones travel?

A

Travel to distant target cells or glands where they exert their effects

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10
Q

Where do neurotransmitters act?

A

Act at synapses
ex. the junctions between nerve cells & their target cells (neuron, muscle, gland)

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11
Q

Where do neurohormones act?

A

Act more broadly on the body, influencing the function of endocrine glands and the release of hormones

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12
Q

What hormones do the posterior pituitary release?

A

Releases Oxytocin (OT) and antidiuretic hormone (ADH)

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13
Q

What is oxytocin responsible for?

What is ADH (vasopressin) responsible for?

A

Uterine contractions, milk ejection, positive mood (bliss, love, bonding)

Retention of fluid by the kidneys

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14
Q

Where does the neurohormones that the posterior pituitary releases come from?

A

These neurohormones are made in the hypothalamus.

15
Q

What is the posterior pituitary similar to?

A

A collection of nerve endings

16
Q

What are low levels of oxytocin associated with?

A
  • Conditions such as ASD (implicated in social cognition & behaviour)
  • Depression, anxiety, & stress
  • Higher levels of perceived pain
17
Q

When dooxytocin levels naturally increase?

A

Levels increase in breastfeeding individuals
* Initiate let-down & milk ejection
* Calming effect on mother

18
Q

What is ADH also know as?

A

Vasopressin

19
Q

What does ADH play an important role in?

A

Important role in blood pressure regulation

20
Q

When is there an increased release of ADH? (heart)

A

Increased release with heart failure
* Mechanism to support blood pressure in response to reduced blood flow
* Leads to water retention & fluid overload that tends to worsen heart failure symptoms

21
Q

When is there an increased release of ADH (response to something)

A

Increased release in response to severe blood loss or dehydration
* Mechanism to try to increase water retention & maintain blood pressure
* Hypovolemic shock can be life threatening

22
Q

What does the anterior pituitary act like and why does it act like this?

A

Acts like a gland
-Contains endocrine cells that release many hormones

23
Q

Anterior pituitary is a…

A

Multi-organ hormone axis

24
Q

What do the following stand for?
GHRH
IGF-1

A

Growth hormone releasing hormone
Insulin-like growth factor

25
Q

What is GHRH stimulated by?

A

Stimulated by sex hormones and deep sleep

26
Q

What effects do IGF-1 have?

A

anabolic effects

27
Q

What can GH do in adulthood?

A

Help skull and facial bone grow

28
Q

Why are anabolic steroids/GH harmful

A

-The effective dose is more than is naturally in the body
-Our hormones are released according to ultradian, circadian and infradian rhythms, but dose of the hormone/hormone agonist is generally not timed to mimic natural hormone production

29
Q

What can hormones be used as? (badly)

A

As ergogenic aids, many are banned due to significant health risks.