Lecture 1: Auditory Tracts Flashcards
Where do the primary afferents from the cochlear division of CN VIII enter the brainstem?
Considered 1st order neuron
Pontomedullary junction
Where do the ascending and descending bundles of primary afferent CN VIII synapse?
- Ascending Bundle: Anterior subdivison of ventral cochlear nucleus
- Descending Bundle: Posterior subdvision of ventral cochlear nucleus and dorsal cochlear nucleus
What is the function of the dorsal cochlear nuclei?
- Identifying sound source elevation
- Identifying complex spectral characteristics of sound
What is the function of the ventral cochlear nucleus?
Horizontal localization of sound
What is the function of the monaural tract?
Information about sounds at a single ear
Where are the primary cell bodies located in the monaural tracts?
Dorsal Cochlear Nucleus
Where does the monaural tract cross to the contralateral side?
Pons via dorsal acoustic stria
What are the points of synapse in the monaural tracts?
- Inferior Colliculus
- Medial Geniculate Nucleus
- Layer IV of Primary Auditory Cortex (Heschl’s Gyrus)
Fibers from the monaural tract travel through what part of the internal capsule to reach the primary auditory cortex?
Sublenticular limb of the internal capsule
What is the function of the binaural tract?
Differences between sounds at both ears
Role in localization of sound
What are the points of synapse of the binaural tract?
- Superior Olivary Nucleus
- Inferior Colliculus
- Medial Geniculate Nucleus
- Layer IV of Primary Auditory Cortex (Heschl’s Gyrus)
What structure does the binaural fibers pass through to reach the super olivary complex?
Trapezoid body in the pons
What is conduction deafness?
How can that occur?
Obstructed or altered transformation of sound external and middle ear
- Damage/Infection to tympanic membrane
- Damage to ossicles
- Build up of earwax
What is sensorineural deafness?
How does it occur?
Ipsilateral deafness due to damage in the inner ear
- Damage to cochlea
- Hair Cells
- Spiral Ganglion Cells
- Damage to cochlear part of CN VIII
- Damage to cochlear nuclei
What is central deafness?
What is its symptoms?
Theoretically not deaf but there is damage to central pathways (past superior olivary complex)
- Cannot localize sound
- Hard to follow conversations in noisy areas
What supplies the cochlea and auditory nuclei of pons and medulla?
Basilar Artery
Occlusion of what branch of the Basilar Artery will cause monaural hearing loss?
AICA
Can also damage Facial Nerve
What supplies the superior olivary complex and lateral lemniscus?
Short circumferential branches of Basilar Artery
What supplies the inferior colliculus?
Superior Cerebellar Artery
Quadrigeminal Artery from PCA
What supplies the medial geniculate body?
Thalamogeniculate Artery from PCA
What supplies to the primary auditory and association cortices?
M2 segment of Middle Cerebral Artery
What is the function of Wernicke’s area?
Comprehension of spoken and written language
- Word representation
- Word retrieval
What is the function of Broca’s area?
- Instruction for language output
- Planning movements to produce speech
- Articulation
- Providing grammatical function of words
- Syntax
What is the function of the area analogous to Wernicke’s area?
Interpreting nonverbal signs from other people
- Body language
What is the function of the area analagous to Broca’s area?
Instructions for producing non-verbal communication (i.e. emotional gestures and intonation of speech)
What fibers connect Wernicke’s and Broca’s areas?
Arcuate fibers (allow verbal repetition)
What is the process to produce language?
- Primary Auditory Cortex: auditory discrimination
- Auditory Association Cortex: classification of sounds
- Wernicke’s Area: comprehension
- Arcuate Fibers: link Wernicke to Broca’s Area
- Broca’s Area: language output
- Sensorimotor Cortex: cortical output to speech muscles:
What is the function of the lateral temporal cortex?
Semantic Knowledge: sentences will make sense
Word recognition (meaning)
What is agnosia?
Inability to identify an object despite being able to perceive it
What is auditory agnosia?
Inability to describe a sound that has been heard
What has been damaged in auditory agnosia?
Bilateral temporal cortex in the sensory association cortex
Lesion is unimodal sensory association cortex (bilaterally)
What is Wernicke’s aphasia?
Receptive or Fluent Aphasia
- Unable to comprehend language in any form
- Cannot write or read (can still speak)
- Word salad: speech makes no sense
- Not aware of their own problem
What is Broca’s Aphasia?
Expressive or non-fluent aphasia
- Loss of ability to speak fluently
- Speech is slow, labored, poor enunciation
- Can understand spoken and written language
- Telegraphic Speech: nonessential words are omitted
What area has been damaged in transcortical motor aphasia?
Is the patient fluent or nonfluent?
ACA-MCA border zone infarction
Nonfluent
What area has been damaged in a transcortical sensory aphasia?
Is the patient fluent or nonfluent?
MCA-PCA border zone
Fluent
What is Global Aphasia?
What can cause it?
Lesion of lateral sulcus: Broca’s and Wernicke’s areas damaged
- MCA occlusion
- Cannot speak or understand
- Non-fluent
What is conduction aphasia?
How does it occur?
Lesion to supramarginal gyrus and arcuate fasciculus
- Fluent aphasia
- Cannot repeat
- Good comprehension
- Can read but cannot write
- Word finding difficulty
A patient is able to tell you his history and read normally but cannot write. He is able to converse, however he is unable to repeat words you say to him. What type of aphasia is this?
Conduction aphasia
What are the nonfluent aphasias?
Comprehension Still Intact
- Broca’s aphasia
- Transcortical motor aphasia
Comprehension Not Intact
- Mixed transcortical aphasia
- Global aphasia
Repetition is preserved in what aphasic syndromes?
Transcortical motor
Transcortical sensory
Anomic Aphasia
Which transcortical aphasia presents similar to Broca’s area?
Transcortical motor aphasia
Which transcortical aphasia presents similar to Wernicke’s aphasia?
Transcortical Sensory Aphasia
What is anomic aphasia?
Word finding difficulties