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immunology > lect 13- effector mechanisms of humoral immunity > Flashcards

lect 13- effector mechanisms of humoral immunity Flashcards

1
Q

what is the protective mechanism of polio vaccine

A

neutralization of virus by mucosal IgA Ab

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2
Q

what is the protective mechanism of tetanus & diphtheria

A

neutralization of toxin by systemic IgG Ab

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3
Q

what is the protective mechanism of Hep A and B

A

neutralization of virus by mucosal IgA or systemic IgG Ab

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4
Q

what is the protective mechanism of pneumococcal pneumonia, haemophilus

A

opsonization and phagocytosis mediated by IgM and IgG Abs, directly or secondary to complement activation

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5
Q

how do influenza viruses infect respiratory epithelial cells

A

their envelope hemagglutin

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6
Q

how do gram negative bacteria infect host cells

A

pili

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7
Q

how do IgG isotope coat opsonize microbes and promote their phagocytosis by binding to ______ on phagocytes

A

Fc receptors

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8
Q

what is the cell distribution of FcgammaRI and function

A

cell distribution: macrophages, neutrophils, eosinophils and function is phagocytosis and cell activation

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9
Q

what is the cell distribution and function of FcgammaRII

A

macrophages, neutrophils, DCs, B cells, NK cells and function is phagocytosis, cell activation, and feedback inhibition

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10
Q

what is the function and cell distribution of FcgammaRIII

A

NK cells and Ab-dependent cell-mediated cytotoxicity

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11
Q

what is the function and cell distribution of FcepsilonRI

A

mast cells, basophils, eosinophils and cell activation is function

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12
Q

what are the most efficient opsonins for promoting phagocytosis and how

A

IgG1 and IgG3 via high affinity FcgammaRI

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13
Q

what does perforin do

A

induces uptake of granzymes into target cell endosome and release into cytosol, activating caspases

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14
Q

how can worms be killed

A

by toxic cationic protein (major basic protein)

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15
Q

what is the function of factor B

A

Bb is a serine protease and the actin enzyme of the C3 and C5 convertases

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16
Q

what is the function of factor D

A

plasma serine protease cleaves factor B when it is bound to C3b

17
Q

what is the function of properdin

A

stabilizes C3 convertases (C3bBb) on microbial surfaces

18
Q

what is the function of MASP3

A

associates with collections or ficolins and MASP1 and cleaves C4

19
Q

what is the function of MASP2

A

forms complex with lectins, especially ficolin-3

20
Q

what is the function of MASP1

A

forms complex with MASP2 and collections and ficolins and activates MASP3

21
Q

what is the function of MBL

A

agglutinin, opsonin, complement fixing

22
Q

what are the functions of CR1

A

phagocytosis, clearance of immune complexes, promotes dissociation of C3 converses by acting as cofactor for cleavage of C3b, C4b

23
Q

what is the function of CE2

A

coreceptor for B cell activation, trapping of Ags in GCs, receptor for EBC

24
Q

what is the function of C1 inhibitor

A

serine protease inhibitor

25
Q

what is the function of factor I

A

cleaves C3b and C4b

26
Q

what is the function of factor H

A

binds C3b and displaces Bb, cofactor for factor I-mediated cleavage of C3b

27
Q

what if the function of MCP

A

cofactor for factor I-mediated cleavage of C3b and C4b

28
Q

what is the function of DAF

A

displaces C2a from C4b and Bb from C3b

29
Q

what terminates classical activation

A

C1 INH displaces C1r2s2 from C1q

30
Q

what inhibits the formation of MAC

A

CD59 and S protein

31
Q

what deficiencies are associated with lupus

A

C1q, C2 and C4 deficiencies

32
Q

what is C3 deficiency associated with

A

pyogenic bacterial infections

33
Q

what is a deficiency of properdin and factor D associated with

A

pyogenic bacteria

34
Q

neisseria bacteria is associated with what deficiencies

A

C5, C6, C7, C8 and C9 deficiencies

35
Q

what is complement activation associated with

A

intravascular thrombosis

36
Q

what do many pathogens express that can inhibit the alternative pathway of complement by recruiting Factor H

A

sialic acids

immunology (13 decks)

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