lec6 : Blood Transfusion Flashcards
Indications of Blood Transfusion
Hemorrhage , Severe anemia , Erythroblastosis fetalis
Cross matching test………………….
“The donor’s cells are added to the recipient plasma
why you should do Cross matching test befor Blood Transfusion?
to avoid incompatibility
due to any subgroup, or due to increased
concentration of agglutinins in the donor’s
plasma.
addition…………….. to the blood to prevent its clotting
acid citrate
addition …………… to the blood as a nutrient to the RBCs
glucose
The blood should be kept at a temperature of ……. not frozen
4º C
The blood should not be used after…………. weeks
5
releasing Hb into plasma causing ………….
jaundice
…………………….. release from the hemolyzed RBCs causing vasodilatation and resulting in hypotension
Histamine
Acute kidney shut down.due to
a-Ag-Ab reaction -> release of toxic substances from hemolysed RBCs -> renal V.C. -> dec GFR
b- circulatory shock -> toxic substances -> dec GBF and urine output
c- renal tubular blockage by precipitated hemoglobin ( acidic urine + HB -> acid hematin)
Immediate dangers of blood Transfusion.
Acute hemolytic (Incompatibility) reactions ,
Febrile Reactions ,
Allergic Reactions ,
Mechanical overloading of the circulation ,
Hyperkalemia ,
Citrate intoxication ,
Bacterial infection
Prolonged storage at room temperature (more than 4 hours) ……………………………….
encourages the growth of contaminating bacteria.
Delayed dangers of blood Transfusion…
Transmission of diseases e.g. AIDs, hepatitis,
malaria and syphilis.
Iron overload.
