interactive lecture 1-3 Flashcards
Blood viscosity is……….
5 times water
Blood specific gravity
1.060
Blood is formed of
Plasma 55%and blood cells 45%
Blood fluid part is called…………..
Plasma
Plasma …………….. blood volume
55% blood volume - 3.5 liters
plasma proteins content ……….
6-8 gm%
All proteins are formed in —- except ——
Liver, except gamma globulin
The most abundant, smallest molecular weight
Albumin
Albumin function
Maintain effective plasma osmotic pressure
Effective plasma osmotic pressure
Plasma osmotic pressure exceeds interstitial fluid osmotic pressure by 25 mmHg
This will pull fluid back to plasma
Albumin
Effective osmotic pressure
Globulin
Immunity
fibrinogen
coagulation
Hb level
male …………..
female ……….
male 15-17 gm%
female 13-15 gm%
RBCs count
male …………..
female ……….
male : 5-6 million/mm3
female : 4-5 million/mm3
Hematocrit value
male …………..
female ……….
male : 45-47%
female : 43-45%
Functions of RBCs membrane:
1- Concave to help gas exchange
2-plasticity
3- keep Hb inside
4- blood groups
Hb F
higher affinity to oxygen,
Disappear 2,3 months after birth
Blood groups are classified according to …………………..
antigens on RBCs membrane
Iron of the Hb remains in the……………….
ferrous state
Site of RBCS formation
Bone marrow
Secreted by kidney in response to hypoxia
Erythropoietin hormone
Form the heme part of Hb
Iron
Responsible for DNA maturation and cell division
Vitamin B12
Secreted by stomach parietal cells to help vitamin B12 absorption
Intrinsic factor
……………Inhibit ferroportin to prevent iron overload
Hepcidin
………………..Transport iron through basolateral cell border
Ferroportin
………Transport form of iron in blood
Transferrin
Transport iron from lumen to intestinal cell
Divalent metal transporter-1
Normal storage form of iron in liver
Ferritin
Pathological iron storage form in iron overload
hemosidrin
Bone marrow failure
Aplastic anemia
Microcytic hypochromic anemia
Iron deficiency
Macrocytic anemia
Folic acid deficiency
Pernicious anemia
Vitamin B12 deficiency
Sickle cell anemia
Hb S
Spectrin genetic defect
Spherocytosis