LEC INFLAMMATION, TISSUE HEALING AND REPAIR Flashcards

1
Q

composed of a series of physiologic and morphological changes in the blood vessels, blood components and surrounding connective tissue for the purpose of protecting the body against injury

A

INFLAMMATION

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2
Q

CARDINAL SIGNS OF INFLAMMATION

A

Calor- heat
Rubor- redness
Tumor- swelling
Dolor- pain
Functio Laesa- loss of function

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3
Q

Sequence of events in an inflammatory reaction

A

Offending agent is recognized by host cells
Leukocytes and Plasma proteins are recruited from the circulation to the site where the offending agent is located
Leukocytes and Protein are activated to eliminate offending substance
Reaction is controlled and terminated
Damaged tissues is repaired

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4
Q

2 types of inflammation

A

Acute- Fast mins or hrs, mainly neutrophils, self limiting and mild, prominent
Chronic- Slow days, monocytes, macrophages and lymphocytes, severe and progressive, less prominent

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5
Q

2 Major Components of Inflammation

A

Vascular Changes- dilation of small vessels leading to an increase in blood flow

Cellular Events- emigration of leukocytes from the microcirculation, accumulation in the injury and activation to eliminate offending agent

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6
Q

Stimuli for Acute Inflammation

A

Infections
Tissue Necrosis
Foreign Bodies
Immune Reactions

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7
Q

Hallmarks of Morphologic Patterns of Acute Inflammation

A

Dilation of small blood vessels
Accumulation of leukocytes and fluid in the extravascular tissue

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8
Q

Type of inflammation in which is marked by exudation of protein-poor fluid into spaces created by cell injury

A

Serous Inflammation

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9
Q

Samples of Serous Inflammation

A

Skin Blisters due to burns

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10
Q

Type of inflammation that has large molecules pass out of the blood and fibrin is formed and deposited in the extracellular space

A

Fibrinous Inflammation

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11
Q

This inflammation is caused by infection with bacteria that cause liquefactive tissue necrosis

A

Purulent/Suppurative Inflammation

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12
Q

Sample of Purulent/Suppurative Inflammation

A

Acute Appendicitis

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13
Q

A local defect or excavation of the surface of an organ or tissue

A

Ulcers

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14
Q

A mediator which causes vasodilation, increase vascular permeabiliy and endothelial activation

A

Histamine

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15
Q

This mediator acts by vasodilation, pain, fever

A

Prostaglandins

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16
Q

This mediator acts by increasing vascular permeability, chemotaxis, leukocyte adhesion and activation

A

Leukotrienes

17
Q

This mediator acts by activation of adhesion molecules in systemic fever, metabolic abnormalities and hypotension

A

Cytokines

18
Q

This mediator action is chemotaxis and leukocyte activation

A

Chemokines

19
Q

This mediator acts as a vasodilator, degranulation, increased vascular permeability, leukocyte adhesion, chemotaxis and oxidative burst

A

Platelet Activating Factor

20
Q

This mediator acts by activating leukocyte and its chemotaxis, vasodilation

A

Complement

21
Q

This mediator acts by increasing vascular permeability, smooth muscle contraction activation, vasodilation, pain

A

Kinins

22
Q

Properties of cell mediators

A

Cell-derived- sequestered in IC granules and can be rapidly secreted by granule exocytosis
Plasma-derived- produced mainly in the liver and present in the circulation as inactive precursor

23
Q

2 Vasoactive amines

A

Histamine
Serotonin

24
Q

2 Arachidonic Acid metabolites

A

Prostaglandins
Leukotrienes

25
Q

This is the response of prolonged duration in which inflammation, tissue injury and attempts at repair coexists

A

Chronic Inflammation

26
Q

Causes of Chronic Inflammation

A

Persistent infections
Hypersensitivity diseases
Prolonged exposure to potentially toxic agents

27
Q

A form of Chronic Inflammation that is characterized by collections of activated macrophages and sometimes associated with central necrosis

A

Granulomatous inflammation

28
Q

2 types of Granulomatous Inflammation

A

Foreign Body Granuloma- driven by inert foreign bodies in the absence of T cell-mediated immune response
Immune Granuloma- by persistent microbe or self antigen

29
Q

Samples of diseases under Granulomatous Inflammation

A

Tuberculosis, Leprosy, Syphilis, Cat-scratch disease, Sacoidosis, Crohn Disease

30
Q

Major causes of granulomatous inflammation

A

Bacterial: Tuberculosis, Syphilis, Cat-Scratch
Fungal: Histoplasmosis, Cryptococcus, Coccidioidomycosis, Blastomycosis
Helminthic: Schistosomiasis
Protozoal: Leishmaniasis, Toxoplasmosis
Chlamydia: Lymphogranuloma venerum

31
Q

Systemic Effects of Inflammation

A

Fever
Acute Phase proteins
Leukocytosis
Increase pulse and BP, decrease sweating

32
Q

It refers to the repair of tissue architecture and its function

A

Tissue Repair/Healing

33
Q

2 Types of reaction under tissue repair

A

Regeneration
Scar formation

34
Q

Factors influencing tissue repair

A

Infection
DM
Nutritional Status
Glucocorticoids
Mechanical Factors
Poor perfusion
Foreign bodies
Type and extent of tissue injury
Location of injury

35
Q

What are the episodes in first intention of Skin wound healing

A

Clot forms within 24 hours
Fast healing
By 3-5 days macrophages come in
Week after granulation tissue is gone

36
Q

What are the episodes in second intention of Skin wound healing

A

Fibrosis predominates over
Healing is slower with more inflammation and granulation
more scarring