LEC INFLAMMATION, TISSUE HEALING AND REPAIR Flashcards
composed of a series of physiologic and morphological changes in the blood vessels, blood components and surrounding connective tissue for the purpose of protecting the body against injury
INFLAMMATION
CARDINAL SIGNS OF INFLAMMATION
Calor- heat
Rubor- redness
Tumor- swelling
Dolor- pain
Functio Laesa- loss of function
Sequence of events in an inflammatory reaction
Offending agent is recognized by host cells
Leukocytes and Plasma proteins are recruited from the circulation to the site where the offending agent is located
Leukocytes and Protein are activated to eliminate offending substance
Reaction is controlled and terminated
Damaged tissues is repaired
2 types of inflammation
Acute- Fast mins or hrs, mainly neutrophils, self limiting and mild, prominent
Chronic- Slow days, monocytes, macrophages and lymphocytes, severe and progressive, less prominent
2 Major Components of Inflammation
Vascular Changes- dilation of small vessels leading to an increase in blood flow
Cellular Events- emigration of leukocytes from the microcirculation, accumulation in the injury and activation to eliminate offending agent
Stimuli for Acute Inflammation
Infections
Tissue Necrosis
Foreign Bodies
Immune Reactions
Hallmarks of Morphologic Patterns of Acute Inflammation
Dilation of small blood vessels
Accumulation of leukocytes and fluid in the extravascular tissue
Type of inflammation in which is marked by exudation of protein-poor fluid into spaces created by cell injury
Serous Inflammation
Samples of Serous Inflammation
Skin Blisters due to burns
Type of inflammation that has large molecules pass out of the blood and fibrin is formed and deposited in the extracellular space
Fibrinous Inflammation
This inflammation is caused by infection with bacteria that cause liquefactive tissue necrosis
Purulent/Suppurative Inflammation
Sample of Purulent/Suppurative Inflammation
Acute Appendicitis
A local defect or excavation of the surface of an organ or tissue
Ulcers
A mediator which causes vasodilation, increase vascular permeabiliy and endothelial activation
Histamine
This mediator acts by vasodilation, pain, fever
Prostaglandins