LEC 11: Dementia Flashcards
What is physiology of dementia?
- Is a terminal disease
- Caused by treatable and non-treatable conditions
- Most often occurs on older adults
What is physiology of dementia of Alzheimer’s Disease?
Changes the brain structure and function
- Amyloid plaques
- Neurofibrillary tangles
- Loss of cholinergic neurons
What are the risk factors fro dementia?
- Smoking
- Cardiac
- Dysrhythmias
- Hypertension
- Hypercholesterolemia
- Diabetes
- CAD
What are the risk factors for Alzheimer’s disease?
- Genetic factors
- Old age
- CVD
- Depression
- Head injury
- Lack of intellectual stimulation
What are the 10 warning signs of Alzheimer’s disease?
- Memory loss that affects day to day activities
- Difficulty performing familiar tasks
- Problems with language
- Disorientation in time and space
- Impaired judgment
- Problems with abstract thinking
- Misplacing things
- Changes in mood and behaviour
- Changes in personality
- Loss of initiative
Clinical Manifestations of Alzheimer’s Disease
- Progression is variable, ranges fro 3 to 20 years
- Initial signs subtle detoriation in memory
- Progressed to more profound memory loss
- Easier to recognize when family members or individuals seek medical help
What are the early signs of Alzheimer’s disease?
- Memory loss that affects job skills
- Difficulty performing familiar skills
- Problems with language
- Disorientation to time and palce
- Poor judgment
- Misplacing things
- Changes in mood, behaviour, or personality
What are the middle or moderate signs/stage of Alzheimer’s disease?
- Increasing memory loss (including remote)
- May start to not recognize family members
- Difficulty with speech and written language
- Challenges with ADLs
- Require supervision for safety
- Wandering
- May become ompulsive
What are the middle or late signs/stage of Alzheimer’s disease?
- Significant loss of memory
- Unable to communicate
- Cannot perform ADLs
- May be unresponsive
- Eventual incontinence
- Require total care
- Refusing food a signal of the end-stage
How can you assess Alzheimer’s disease?
- Diagnosis of exclusion
- Comprehensive patient evaluation (blood work, cognitive screening, asses for depression)
- Brain imaging test not commonly used but can be (MRI, PET)
Why are brain imaging test usually not done?
Because plaques and tangles do not show up on brain imaging and tests are costly
What can testing of Alzheimer’s disease accomplish?
Testing can help document degree of cognitive impairment
- Monitoring in early stages and tx response
What is the only sure way to tell if someone has Alzheimer’s disease?
Only an autopsy can determine a definitive diagnosis
What is the goal for Alzheimer’s disease treatment?
Collaborative management aimed at:
- Slowing the decline of cognitive impairment
- Maxamizing quality of life
What is the drug therapy used in Alzheimer’s disease?
a. Cognition
- Doneprezil, memantine
b. Behaviour
- Risperidone, quetiapine
c. May use anti-depressant such as SSRIs