LABORATORY BIOSAFETY AND BIOSECURITY Flashcards
origins of biosafety is rooted in the US biological weapons program in year _________
1943
first scientific director of Camp Detrick. He was tasked with establishing the biological weapons programs for defensive purposes
Ira L. Baldwin
US president Richard Nixon terminated such program
1969
he designed modifications for biosafety at Camp Detrick
Newell A. Johnson
He developed Class III safety cabinets and laminar flow hoods to address specific risks.
Newell A. Johnson
formation of American Biological Safety Association (ABSA)
1984
he described the use of mechanical pipettors to prevent laboratory-acquired infections
Arnold Wedum (1907-1908)
year when pharmaceutical company in Pennsylvania developed a ventilated cabinet to prevent infection from Mycobacterium tuberculosis
1909
year when WHO pursued the eradication of the Small pox virus. Serious concerns about biosafety practices worldwide were raised.
1967
year when CDC published the Classification of Etiologic Agent on The Basis of Hazard
1974
CDC published the Classification of Etiologic Agent on The ____________________
Basis of Hazard
year when NIH published the Guidelines for Research Involving Recombinant DNA Molecules. It explained in detail the microbiological practices, equipment and facility necessarily corresponding the four ascending levels of physical containment.
1976
year when published first edition of the biosafety in microbiological and biomedical laboratories. These documents established the model of biosafety containment levels with certain agents.
1984
it is the technical means of mitigating the risk of accidental infection from or release of agents in the laboratory setting as well as in the community and environment it is situated in.
Biosafety levels
they ensure that the proper equipment and facility controls are in placed based on the specified biosafety levels of the laboratory
Biosafety officers
year when Alfred Wedum and Morton Reitman analyzed multiple epidemiological studies of laboratory-based outbreaks.
1966
________ and ________ analyzed multiple epidemiological studies of laboratorybased outbreaks.
Alfred Wedum and Morton Reitman
year when US government enacted the Select Agent Regulations to monitor the transfer of select list of biological agents
1906
year when of Select Agent Regulations was revised
2012
law that established four schedules of select agents that are subject to different reporting and handling requirements
Infectious Disease Control Law
Other countries biosecurity regulations for bioscience facilities:
- Biological Agents and Toxins Act
- Act on Prevention of Infectious Diseases (2005)
- Infectious Disease Control Law
this act/law require institutions that work with listed âhighly dangerous pathogensâ to implement laboratory biosafety and biosecurity requirements.
Act on Prevention of Infectious Diseases (2005)
published the CEN workshop agreement 15793.
Comité Européen de Normalisation
This agreement intended to maintain a biorisk management system among diverse organizations and set out performance-based requirements for implementing a national biosafety system
Comité Européen de Normalisation
INTERNATIONAL GUIDELINES LABORATORY that includes information on the different levels of containment laboratories (biosafety levels 1-4), different types of biological safety cabinets, good microbiological techniques and how to disinfect and sterilize equipment.
Laboratory Biosafety Manual
provides an international regulatory framework to ensure âan adequate level of protection in the field of safe transfer, handling and the use of living modified organism resulting from modern biotechnologyâ
Cartagena Protocol on Biosafety
Procedures:
Evaluation of proposal for biosafety concerns
Procedures and guidelines on the introduction, movement and field release of regulated materials
Physicochemical and biological containment
National Committee On Biosafety Of The Philippines (NCBP)
it promotes biosafety as a scientific discipline and provides guidance to its members on the regulatory regime present in North America
American Biological Safety Association
acts as a professional society for biosafety professionals in Asia - pacific region. Active members of the international biosafety working group are required to directly contribute to the development of the best biosafety practices.
Asia Pacific Biosafety Association
focuses on encouraging and communicating among its members information and issues on biosafety and biosecurity as well as emerging legislation and standards
European Biological Safety Association (EBSA)
assist DA and DOH in their efforts to create a national policy and implement plan for laboratory biosafety and biosecurity
Philippine Biosafety And Biosecurity Association (PhBBA)
a non government and non profit association that works to serve the emergent concerns of biological risk management in various professional fields such as in health, agriculture and technology sectors throughout the country.
Biological Risk Association Philippines (BRAP) -
Containment principles, technologies and practices that are implemented to prevent unintentional exposure to pathogens and toxins, or their accidental release.
Biosafety
refers to the protection, control and accountability for valuable biological materials within laboratories, in order to prevent their unauthorized access, loss, theft, misuse, diversion or intentional release
Biosecurity
he created the biohazard symbol used in labeling biological materials carrying significant health risks
Charles Baldwin
focuses on the laboratory procedures and practices necessary to prevent exposure to and acquisition of infections
Biosafety
focuses on the maintenance of secure procedures and practices in handling biological materials and sensitive information
Biosecurity
Risk group classification for humans and animals is based on agentâs:
Pathogenicity Mode of transmission Host range Availability of preventive measure Effective treatment
includes microorganisms that are unlikely to cause human or animal disease.
Risk group 1
includes microorganisms that are unlikely to be a significant risk to laboratory workers and community, livestock or environment. Laboratory exposure may cause infection, however, effective treatment and preventive measures are available while the risk of spread is limited.
Risk group 2
include microorganisms that are known to cause serious diseases to humans or animals and may present a significant risk to
Risk group 3
includes microorganisms that are known to produce life threatening diseases to humans or animals. It represents a significant risk to laboratory workers . They bring about high individual and community risk.
Risk group 4
is suitable for work involving viable microorganisms that are defined and with well- characterized strains known not to cause disease in humans.
Biosafety level 1 (BSL-1)
is basically designed for laboratories that deal with indigenous moderate risk agents present in the community. It observes practices equipment, and facility design that are applicable to clinical, diagnostic and teaching laboratories consequently observing good
Biosafety level 2 (BSL-2)
puts emphasis on primary and secondary barriers in the protection of the personnel, the community, and the environment from infectious aerosol exposure
Biosafety level 3 (BSL-3)
Is required for work with dangerous and exotic agents that pose high individual risks of life-threatening diseases that may be transmitted via the aerosol route, for which there are no available vaccines or treatment.
Biosafety level 4 (BSL 4)
