Lab_GIT Flashcards

1
Q

stimulate acid
secretion

A
  • Acetylcholine * Histamine * Gastrin
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2
Q

inhibits acid secretion

A

somatostatin

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3
Q

Physical barrier between the lumen and
epithelium

A

Mucous neck cell (Mucus)

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4
Q

Buffers gastric acid to prevent epithelial
damage

A

Bicarbonate

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5
Q

Activates pepsin; Kills bacteria

A

Parietal cell [Gastric acid (HCl)]

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6
Q

Vitamin B12 absorption

A

Intrinsic factor

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7
Q

Stimulates gastric acid secretion

A

Enterochromaffin-like cell (ECL)
[Histamine]

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8
Q

Protein digestion

A

Chief cell (Pepsin)

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9
Q

Stimulates gastric acid secretion

A

Antral G cells (Gastrin)

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9
Q

Fat digestion

A

Gastric lipase

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10
Q

Inhibits gastric acid secretion

A

Antral D cells (Somatostatin)

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11
Q

Tertiary amine belladonna alkaloid

A

ATROPINE

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12
Q

cholinergic antagonist

A

ATROPINE

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13
Q

Atropine competes with ________ at the muscarinic
receptors causing blockade of cholinergic
effects → ________ GI motility

A

Ach ; decrease

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14
Q

T/F: Atropine is reversible

A

T

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15
Q

Therapeutic use of atropine

A

Antispasmodic

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16
Q

indirectly acting cholinergic agonist
(acetylcholinesterase inhibitor)

A

NEOSTIGMINE

17
Q

Neostigmine MOA: : carbamate esters by binding
with ______________ →
increases Ach at the synaptic cleft →
________ cholinergic effects → increase GI motility

A

acetylcholinesterase; increase

18
Q

Selective anticholinergic with antispasmodic
activity

A

DICYCLOMINE

19
Q

Inhibit muscarinic cholinergic receptors

A

DICYCLOMINE, N-HYOSCINE-BUTYLBROMIDE

20
Q

Direct smooth muscle relaxant

A

DICYCLOMINE

21
Q

No effect on gastric acid secretion

A

DICYCLOMINE

22
Q

Use of DICYCLOMINE

A

Antispasmodics

23
Q

Synonyms of DICYCLOMINE

A

Dicycloverine

24
Q

T/F: N-HYOSCINE-BUTYLBROMIDE also Inhibit muscarinic cholinergic receptors

A

T

25
Q

Use of N-HYOSCINE-BUTYLBROMIDE

A

Antispasmodics

26
Q

Synonym of N-HYOSCINE-BUTYLBROMIDE

A

Scopolamine butylbromide

27
Q

ANTIDIARRHEAL AGENTS

A

Opioid agonist – Loperamide, Diphenoxylate
Kaolin & Pectin (Kaopectate

28
Q

inhibition of presynaptic cholinergic nerves

A

Loperamide, Diphenoxylate

28
Q

Loperamide, Diphenoxylate are used as

A

treatment of diarrhea

29
Q

Kaolin (hydrated magnesium silicate or attapulgite) + pectin
(indigestible carbohydrate derived from apples)

A

Kaopectate

30
Q

adsorbent of bacteria, toxins and fluid → decreasing
stool liquidity

A

Kaopectate

31
Q

Kaopectate is used as

A

Antidiarrheal

32
Q

Bile salt binding resins adsorb bile salt (which cause secretory
diarrhea and __________

A

C. difficile toxin

32
Q

Bile salt binding resins (e.g. cholestyramine,
colestipol) use

A

treat diarrhea caused by C. difficile and bile salts

33
Q

regulatory peptide slows GI motility and
intestinal fluid secretion

A

Somatostatin, Octreotide

34
Q

effective for diarrhea due to vagotomy,
short bowel syndrome

A

Somatostatin, Octreotide

35
Q

Agents that Reduce Gastric Acidity

A

Antacids
* H2-receptor antagonist
* Proton pump inhibitor

36
Q

Mucosal protective agents

A
  • Sucralfate
  • Prostaglandin analog (Misoprostol)
37
Q

Laxatives

A
  • Bulk
  • Osmotic
  • Stool softener
  • cathartic