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Molecular Basis Of Disease/ Microbiology And Immunology > Lab Investigation Of The Full Blood Count And White Cell Disorders > Flashcards

Lab Investigation Of The Full Blood Count And White Cell Disorders Flashcards

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Biology 101 flashcards
1
Q

What are the first steps in normal haematopoiesis?

A

Multipotent haematopoietic stem cell divides into a lymphoid or myeloid stem cell

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2
Q

What do lymphoid stem cells divide into?

A

Lymphoblast
-> natural killer cells
Or
-> T and B lymphocytes

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3
Q

What does a myeloid stem cell divide into?

A

Megakaryoblast
Proerythroblast
Myeloblast
Monoblast

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4
Q

What do monoblasts differentiate into?

A

Monocytes

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5
Q

What do myeloblasts differentiate into?

A

Basophil
Neutrophil
Eosinophil

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6
Q

What do proerythroblasts differentiate into?

A

Reticulocyte -> erythrocyte

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7
Q

What do megakaryoblasts differentiate into?

A

Megokaryocytes

Platelets

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8
Q

What is in a full blood count?

A 
Hb concentration
HCt
MCV
MCH
RDW
Reticulocyte count
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9
Q

What is HCt?

A

Haematocrit = percentage of blood volume as RBC

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10
Q

What is MCV?

A

Mean corpuscular volume = average size of RBC

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11
Q

What is MCH?

A

Mean corpuscular haemoglobin = avg Hb content of RBC

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12
Q

What is RDW?

A

Red cell distribution width = range of deviation around RBC size

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13
Q

What is in the white blood cell count?

A 
Total WBC and breakdown of: 
Neutrophils
Lymphocytes
Monocytes
Basophils
Eosinophils
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14
Q

What of the platelets are measured in a FBC?

A

Platelet count and size

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15
Q

What does a blood film do?

A

Confirms number and morphology

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16
Q

How is a FBC processed?

A

Using optical scanner methods and presented in a cytogram

17
Q

How are things shown in a cytogram?

A

Populations of cells are displayed in distinct clusters

18
Q

What are the advantages of an automated haematology machine?

A 
Efficient and cost effective
Accurate and precise
Multiple tests at a time
Reduced labour requirements
Accurate determination of red cell numbers
19
Q

What are the disadvantages of an automated haematology machine?

A

When results are flagged, it needs labour intensive manual examination of blood smear
Comments on red cell morphology cannot be generated
Platelet clumps are counted as one, so low count
Expensive and high running cost

20
Q

What is tear drop poikilocytosis seen in?

A

Myelofibrosis or bone marrow infiltration

Molecular Basis Of Disease/ Microbiology And Immunology (57 decks)

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