Lab 3 & 4

Question 1

Cushing’s disease

Answer 1

Hyperadrenocorticism
syn. 1. Hypercortisolemia
2. cushing’s syndrome

Question 2

Clinical signs of Hyperadrenocorticism

Answer 2

Polyuria; polydipsia
polyphagia
panting
abdominal distention
hepatomegaly
muscle weakness
pot bellied appearance

Question 3

dermatologic signs of Hyperadrenocorticism

Answer 3

Symmetric truncal alopecia
Hyperpigmentation
Comedones
Thin skin
poor hair regrowth

Question 4

Diagnostic process for Hyperadrenocorticism

Answer 4

1. Urinalysis
   2, Chemistry Panel
2. CBC
3. Lddst
4. ACTH stimulation test
5. Urine-cortisol-to-creatinine ratio

Question 5

Urinalysis (Hyperadrenocorticism)

Answer 5

specific gravity < 1.008
Protenuria may be noted and quantified with urine protein-to-creatinine ratio

Question 6

Chemistry Panel (Hyperadrenocorticism)

Answer 6

increased alkaline phosphatase (ALP) activity

Question 7

CBC (Hyperadrenocorticism)

Answer 7

stress leukogram (neutrophilia, lymphopenia, monocytosis and eosinopenia)

Question 8

Forms of Hypoadrenocorticism

Answer 8

1. Primary Hypoadrenocorticism
2. Atypical Hypoadrenocorticism
3. Secondary Hypoadrenocorticism

Question 9

Adrenal destruction is purported to spare the glomerulosa layer, resulting in an isolated glucocorticoid deficiency.

Answer 9

Atypical Hypoadrenocortcicism

Question 10

results from immune-mediated destruction of adrenal cortical tissue. the adrenal glands don’t make enough of the hormones cortisol and aldosterone

Answer 10

Primary Hypoadrenocorticism

Question 11

refers to a central (anterior pituitary) deficiency of ACTH, resulting in isolated glucocorticoid inusfficiency

Answer 11

Secondary Hypoadrenocorticism

Question 12

Primary hypoadrenocorticism is reported in what ages in dogs

Answer 12

young to middle-aged female dogs

Question 13

Atypical Hypoadrenocorticism is primary seen in what group

Answer 13

Occurs at older ages

Question 14

Clinical signs of mineralocorticoid insufficiency

Answer 14

-Low sodium concentrations
-high potassium concentrations

Question 15

Glucocorticoid insufficiency

Answer 15

Lethargy/weakness
Shaking
Polyuria / Polydipsia
Vomiting / diarrhea
Abdominal pain
Inappetence/ weight loss

Question 16

Gold standard for diagnosis or all forms of hypoadrenocorticism

Answer 16

ACTH stimulation test

Question 17

Treatment for hypoadrenocorticism

Answer 17

Aggressive IV isotonic crystalloids
- Monitoring of packed cell volume / total solids, serum electrolytes, and blood glucose on every 6-8 hours until values have normalized and patients is clinically stable

Question 18

What to avoid in emergency setting for Hypoadrenocorticism

Answer 18

• avoid administration of prednisone, prednisolone and cortisone acetate
• avoid SC admin of DOCP
• avoid PO admin of any medication