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Cell products > L9 > Flashcards

L9 Flashcards

1
Q

What can psychedelics be used to treat?

A

mental illness in combination with psychotherapy

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2
Q

What receptor is activated with psychedelic use?

A

2A receptor in cortex

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3
Q

What is an example of GABAergic psychedelcs?

A

DMT (5MeO-DMT)

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4
Q

What does DMT induce?

A

de novo neurogenesis

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5
Q

What are neurospheres derived from?

A

Neural stem cells from subgranular zone of hippocampus

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6
Q

What receptor is expressed in a high level in neurospheres?

A

Sigma1 receptor (S1R)

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7
Q

What is microdosing?

A

People regularly take small amounts of psychedelic drug

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8
Q

What are benefits of microdosing?

A

Improved mood
better sex life

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9
Q

When does drug exposure in foetal drug experience occur?

A

Occur before homeostatic regulatory mechanisms are properly calibrated - affect foetal brain development

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10
Q

What % of pregnant women take drugs?

A

5.9%

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11
Q

What can transcriptomics tell us?

A

Development of human brain

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12
Q

What is Laser Capture microdissection used for?

A

isolate specific areas of brain during development

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13
Q

What does RNA-seq build?

A

Atlas of gene expression in different areas during development

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14
Q

What is Spatial transcriptomics?

A

Laser Capture Micro-dissection followed by RNAseq

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15
Q

What are 4 pros of single cells approach?

A

More coverage
More cell types
rare cel types
pseudotemporal mapping

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16
Q

What does downstream analysis of cell-RNA-seq, ATA_seq and proteomics provide?

A

Comprehensive, patient specific view of structural & molecular changes with brain

17
Q

What marker has been shown to accumulate in the nucleus accumbens?

A

Delta FosB & C-Fos

18
Q

What were expressed in the cerebral organoids after cocaine adminstration?

A

FOS
JUNB
JUND
IEGS
increased synpatic plasticity-associated genes (GRID2)

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