L4 Flashcards
1
Q
What did Waddiington’s landscape envisage?
A
Reprogramming as a series of barriers that have to be overcome
2
Q
What are 3 factors that influence phosphorylation-signalling?
A
Multivariate signalling
Cell-to-cell variability
Context dependence
3
Q
What determines cell fate?
A
Environment
4
Q
What 6 biological parameters can we control?
A
Metabolic environment
Cellular complexity
growth factors
immune cells
3-D supports
Shear stress & stiffness
5
Q
Define organotypic culture.
A
Looks and behaves like the organ
6
Q
Define histotypic culture.
A
Looks like the tissue histologically
7
Q
A
