L9 Flashcards

1
Q

what are the basic components needed for CD4+ t cell activation?

A

CD4+ T cell
antigen
antigen-presenting cell (dendritic cell)

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2
Q

there are resident ____ in lymph node paracortext all the time

A

dendritic cells

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3
Q

the resident DC can capture and present ____ draining into lymph nodes from the tissue via lymphatics

A

antiens

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4
Q
A
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5
Q

to fully activate a t cell you need a ____

A

second signall

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6
Q

DCs recognize pathogen assocaited molecules via ___

A

PRRs
pattern recognition receptors

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7
Q

what happens if a t cell recognizes an antigen but doesn’t get co-stimulated?

A

it becomes anergic - unresponsive to anitgen
this is a good way of stopping t-cells getting activated by self-antigen

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8
Q

to achieve CD4+ t cell acitvation, you need

A

recongition of antigen presented by MHCII
and a co stimulatory signal

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9
Q

DCs are specialized to provide signal ___-

A

2

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10
Q

signal 1 in the absnese of signal 2 makes t-cell ____

A

anergic

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11
Q

_____ events are important in supporting t-cell activation

A

cell-adhesion

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12
Q

ICAM-1 is an important ___ molecule

A

cell adhesion

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13
Q

what does ICAM-1 LFA-1 interaction allow?

A

allows t cells to come into close contact with DCs to sample antigens

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14
Q

immunological synapse

A

interactions between CD4+ t cells and DC at point of contact which is known as ^^

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15
Q

clusters of molecules at T-cell-DC interface are called

A

supramolecular activation clusters (SMACs)

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16
Q

pSMAC and cSMAC

A

peripheral and central

17
Q

it is believed that the formation of the immunological synapse faciliatates important signals that promte _____ activation

A

t-cell

18
Q

what happens when a CD4+ t-cell is activated

A

t-cells are first stimulated to proliferate
called clonal expansion = increase number of antigen-specific t cells

19
Q

clonal expansion

A

activated CD4+ t cells begin to express the receptor for the cytokine interleukin 2 on mmebrane

20
Q

the IL-2 secreted can act____

A

in an autocrine manner and a paracrine manner to drive t cell proliferation