L6 Flashcards
antibodies are made by the cells of the ______ lineage
b lymphocyte
antibodies are produced by _____ that differentiate from _______
plasma cells
antigen specific b cells
what do b cells do in the bone marrow?
develop
also where they re-arrange their immunoglobulin genes
independent of antigen but does depend on special cells in the bone marrow - stromal cells
b cells then express their re-arranged immunoglobulin molecule on the membrane surface as ____
IgM class
when the IgM class cells mature, what do they do?
begin to express their re-arranged immunoglobulin molcule as an IgD class
CD19
classic surface protienses to identify b cells
when b cells encounter their specific antigen in lymph nodes, they _____ and eventually ____ into ____ and long lived ____
proliferate
differentiate
plasma cells
memory b cells