L81: Reproduction 3

Question 1

Androstenedione gets converted to ________ in peripheral tissues

Answer 1

Testosterone

Question 2

What does follistatin bind?

Answer 2

activin

Question 3

What does OT promote in breasts?

Answer 3

milk EJECTION not production

Question 4

GnRH binds what kind of receptor on ant pituitary

Answer 4

GPCR

Question 5

Downstream of GnRH binding GPCR, _____ pathway promotes synthesis while ______ pathway promotes secretion of FSH/LH

Answer 5

PKC (synthesis)

IP3 (secretion)

Question 6

GnRH is synthesized from what areas of hypothalamus?

Answer 6

POA and arcuate nucleus

Question 7

What does NOT inhibit secretion of GnRH from hypothalamus?
A. Endorphins
B. Dopamine
C. CRH
D. Norepinephrine

Answer 7

D. NE which promotes secretion of GnRH

Question 8

Clomid is an estrogen receptor antagonist that binds at what organ, thus promoting fertility?

Answer 8

Hypothalamus. Promotes more secretion of GnRH (lacks negative feedback), more LH/FSH, ovulation..

Question 9

SERM

Answer 9

selective estrogen receptor modulator. Confers selective expression or repression of genes bound by ER.

Question 10

An example of a SERM in the context of breast cancer

Answer 10

Tamoxifen

Question 11

3 Menstrual phases

Answer 11

1. Follicular phase
2. Ovulatory phase
3. Luteal phase

Question 12

What does the developing follicle secrete?

Answer 12

E2 and inhibin

Question 13

Inhibin A comes mostly from

Answer 13

Dominant developing follicle

Question 14

Inhibin B comes mostly from

Answer 14

corpus luteum

Question 15

Once E2 synthesis surpasses a certain threshold….

Answer 15

negative feedback on ant. pituitary SWITCHES TO POSITIVE FEEDBACK. LH surge!

Question 16

Ovulation is caused by what spike

Answer 16

LH surge

Question 17

Corpus luteum makes what 3 hormones

Answer 17

E2
Progesterone
Inhibin A

Question 18

During the LH surge
A. Increase in GnRH receptor on ant. pit.
B. Conversion of LH pool to readily releasable
C. Increase in GnRH pulse frequency
D. E2 switch from negative to positive feedback
E. Small rise in progesterone augments LH surge

Answer 18

ALL OF THE ABOVE!