L78: Non-Classical Endocrine Glands

Question 1

Cleaves angiotensinogen to angiotensin 1

Answer 1

renin from JGA

Question 2

Between what two amino acids in angiotensinogen does renin cleave

Answer 2

Leu-Val

Question 3

EPO is regulated by

Answer 3

Anemia
Thyroid hormone
Hypoxia (high alt)
Norepinephrine
Androgens stimulate
Estrogens inhibit

Question 4

Major side effect of raising hematocrit too quickly

Answer 4

hypertension

Question 5

Released in response to stretch in heart

Answer 5

BNP

Question 6

Action of ANP and BNP

Answer 6

vasodilator, increase natriuresis (excretion of Na+), LOWERING EFFECTIVE CIRCULATING BLOOD VOLUME AND PRESSURE

Question 7

Released for atrial myocytes

Answer 7

ANP

Question 8

Released from ventricular myocytes

Answer 8

BNP

Question 9

Which has a higher half-life? BNP or ANP?

Answer 9

BNP; thus useful diagnostic tool

Question 10

Polychlorinated biphenyl (PCB)

Answer 10

Competes with thyroid hormone (T3/T4) for the TBG. Thus circulating T3/T4 is degraded faster, promoting compensatory increase in thyroid hormone production

Question 11

Diethylstilbestrol (DES)

Answer 11

Non-steroidal synthetic estrogen, used in cattle feed, caused congenital deformities (DES daughters), prostate cancer treatment