L68: Endocrinology Basics (part 1)

Question 1

Cretinism etiology?

Answer 1

Congenital

Question 2

Congenital adrenal hyperplasia etiology?

Answer 2

Genetic

Question 3

Etiology of Sheehan’s?

Answer 3

Trauma/stress (in problem set)

Question 4

Etiology of Thyroidectomy?

Answer 4

surgical

Question 5

Etiology of glucocorticoid therapy?

Answer 5

Therapeutic

Question 6

Etiology of DM1

Answer 6

Autoimmune

Question 7

Etiology of endocrine disruptors

Answer 7

environmental

Question 8

What type of hormones need to be bound to proteins in blood

Answer 8

lipophilic

Question 9

Does IGF-1 need a binding protein?

Answer 9

Yes

Question 10

Does GH need a binding protein?

Answer 10

Yes

Question 11

Does T4/T3 need a binding protein?

Answer 11

Yes. Thyroid binding globulin (TBG) and transthyretin (TTR)

Question 12

Does dopamine need a binding protein?

Answer 12

No, it’s a peptide

Question 13

Does insulin need a binding protein?

Answer 13

No, it’s a protein

Question 14

Does cortisol/corticosterone need a binding protein?

Answer 14

Yes; corticotropin binding globulin (CBG)

Question 15

Does estrogen and testosterone need a binding protein?

Answer 15

Yes; SHBG

Question 16

Name a non-specific hormone binding protein

Answer 16

Albumin

Question 17

Can a hormone-BP complex enter into a cell?

Answer 17

Yes, through megalin.

Question 18

Affinity vs. specificity

Answer 18

Affinity is measured by Kd

Specificity is measured by Ki

Question 19

What kind of receptor does GH bind

Answer 19

Receptor linked kinase

Question 20

What kind of receptor does prolactin bind

Answer 20

receptor-linked kinase

Question 21

What kind of receptor does EPO bind?

Answer 21

Receptor linked kinase

Question 22

What kind of receptor does insulin bind?

Answer 22

Receptor kinase

Question 23

What kind of receptor does ANP bind

Answer 23

receptor kinase

Question 24

What kind of receptor does TH bind?

Answer 24

intracellular receptor