L7 Neuro 2 Flashcards
Encephalitis
What is it
Characteristics
What micro is responsible
Inflammation of brain parenchyma
Fatal w/o treatment
Herpes most common
Acute bacterial meningitis
What is it
Caused by
Inflammation of leptomeninges spreads thru subarachnoid space
Caused by pyogenic bacteria
Acute bacterial meningitis characteristics
Purulent exudate under subarachnoid space and w/in ventricles
Tuberculosos meningitis
Characteristics
Chronic
Gelatinous exudate
Cryptococcal meningitis
what is it
Spherical budding yeast found in soil and bird poop
Encephalitis histo findings
Perivascular lymphocytosis
Cowdry type A inclusions
Neurophagia
Microglial nodules
Multiple sclerosis
Demyelinating disorder probably T cell mediated
Areas called MS plaques
Waxing and waning symptoms
Alzheimers disease
Microscopically
Neuritic (senile) plaques (Amyloid plaques)
Neurofibrillary tangles
Parkinsons
What is it
Key feature
Degeneration of dopamine secreting neurons in substantia nigra
Lewy Bodies: eosinophilic inclusions w/in neurons
Huntingtons
Symptoms
Part of brain
spontaneous involuntary movements (chorea)
Dementia
Atrophy of basal ganglia
Most common brain tumor
Astrocytoma
Astrocytoma
Location
Grading
Cerebral hemisphere
II: well differentiated
III: anaplastic
IV: glioblastoma
Astrocytoma grade II
Well differentiated
Mild cellularity
Nuclear pleomorphism
Astrocytoma grade III
Anaplastic
Highly cellular
Mitotic figures
Astrocytoma grade IV
Glioblastoma
Necrosis and microvascular proliferation
