L2 Liver, GB, Pancreas Flashcards
Blood supply of liver
Portal vein
Hepatic artery
Major diseases of the liver
Hepatitis
Alcohol liver
Non alcohol liver (fatty)
Hepatocellular carcinoma
Morphologic changes of Cirrhosis
Bridging fibrous septa
Parnchymal nodules
Causes of portal hypertension with
Prehepatic
Intrahepatic
Posthepatic
Pre: obstructive thrombi
Intra: Cirrhosis
Post: Right sided heart failure
Consequences of portal vein hypertension
Splenomagaly Hypogonadism Excess fluid in peritoneal (ascites) Esophageal varices (veins) Encephalopathy (Brain)
Hep A
Severity
Route of transmission
Benign, self limiting
Fecal oral route
Hep B
Outcomes
Acute hep w/ recovery
Non progressive chronic hep
Progressive w/ cirrhosis
Asymptomatic carrier
Hep B liver disease is precursor for
hepatocellular carcinoma
Hep B
What determines outcome
CD8 T cell damage to hepatocytes
Hep D
What is it
Co infection requiring Hep B
Cure for hep C
Protease and nucleoside inhibitors
Hep E Simliar to Transmission Where does it come from Whom does it affect What is unique about it
Similar to A Enterical transmission (intestines) Water born Pregnanat women Not associated w/ chronic liver disease
Hep G
Detection
Replication
Similar to C
Doesnt increase liver enzymes
Replicates in marrow and spleen
Overlapping forms of alcoholic liver disease
Hepatic steatosis
EtOH hepatitis
Cirrhosis (minority of patients)
Mallory bodies
Clumps of cytokeratins
Eosinophilic cytoplasmic inclusions
