L6 Musculoskeletal Flashcards
Osteogenesis imperfecta is from abnormal development of
Presentation
Collagen Type I
blue sclera
Opalescent teeth
Bone fractures
Osteopetrosis
other name
What is it
Marble bone disease (thick mineral brittle bone)
Deficient osteoclast activity and defective bone remodeling
Osteopetrosis presentation
Chalk bone
Infections
Nerve palsies
Paget disease
Stages
Characteristics
Osteolytic stage: osteoclasts
Mixed osteoclastic-osteoblastic stage
Osteosclerotic phase: exhaustion of cell activity
Gain in bone mass but it is disordered and lacks strength. Dense bone
Leoniasis ossea
what is it
What disease
Lion face, overgrowth of face and cranial bones
Osteomyelitis
What is it
Presentation
Infection in medullary spaces of bone
Non vital sequestrum surround by new involucrum
Osteomyelitis hematogenous spread most frequently caused by
Staphylococcus aureus
Fibrous dyspasia
Features
Chinese characters: Fibrous tissue intermixed w/ unorganized woven bone
Cafe Au Lait
Ground glass
Jaffe lichtenstein
Mccune Albright
Jaffe: Polyostotic fibrous dysplasia w/o endocrine
McCune: Polyostotic fibrous dysplasia w/ endocrine
Osteosarcoma
Common age
Presentation
Location
Before 20
Painful large mass w/ radiopaque/lucent sunburst radio image
Metaphyseal region of long bones in extremities
Codman’s triangle
Acute angle formation between neoplastic bone and cortex in osteosarcoma
Osteophytes
small bony outgrowths in osteoarthritis
Gout attack
Steps
High uric acid Urate crystal Activate complement Neutrophil chemotaxis Dying neutrophils and reacting macrophages release lysosomal enzymes and inflammatory mediators
Duchenne muscular dystrophy
What is it
Type of disorder
X linked recessive disorder
Absence of dystrophin
Symptoms at 3-5, death at 30
Myasthenia gravis
Type of disease
What is it
Population
Autoimmune disease
Destruction of acetylcholine receptors
Females
