L7-Fungi Flashcards
What helps a fungi bind? What part of the host does it bind to?
lectin binds to host’s fibronectin
Why might some parts of our immune system have trouble against fungi? What are the specific parts affected?
Fungi’s excretions destroy antibodies and complement system
What is the main target of antibiotics to a fungal cell? What are the 2 main antibiotics used here?
The ERGOSTEROL component of their cell wall….Az-Oles=stop ergosterol production….and….Poly-enes=make pores in the membrane
What is the chitin wall made of?
beta 1,4 N-AGM
What are the 7 Fungal Pathologies?
1.MycoToxicoses 2.Hypersensativities 3.Superficial Mycoses 4.Cutaneous Mycoses 5.Subcutanueos Mycoses 6.Systemic Mycoses 7.Opportunistic mycoses
Are mycotoxicoses common or rare? What is happening?
these are rare, it is ingestion of fungal toxins/poisons
Are hypersensativities common or rare? What are the two examples given and what type of hypersensitivity reactions are they?
They are COMMON…..Hay Fever & Asthma=Type I(IgE)….Contact Dermatits=Type IV (Cell mediated)
Is Superficial mycoses common or rare? What is happening here?
Common, just the fungi on our skin and hair…no immune resonse
What is the most common of the fungal pathologies? where is it happening on the body?
Cutaneous Mycoses…Skin and Nails
What is cutaneous mycoses caused by? What are the 3 species underneath that main cause?
DERMATOPHYTES….Trichophyton, MicoSporum, EpiderMoPhyTon
Are subcutaneous mycoses common or rare? How are they brought about?
Rare…Fungi/Spores introduced via wounds (Joplin, MO tornado example)
Is Systemic Mycoses rare or common? What is going on here?
Rareish….Lung Infections, like TB..Geographic (valley fever)
What are the 4 opportunistic mycoses from most common to most rare?
1.Candidiasis (oral/vaginal) 2.Cryptococcus (bird poo, lung infect) 3.Aspergillosis (Soil to lungs) 4.Pneumocystis (soil, lung infections in AIDS pt)
What is the #1 culprit for candadiasis? What are the three areas it manifests?
Candida Albicans…1.Oral…2.Esophageal…3.Vaginal
What is the main predisposing factor for Candidiasis?
Lowered immunity! (infants, elderly, other sickness, catheter)
When looking at Candida which is more acidic: yeast or mold?
Yeast (single cell) is more acidic
Which is more common, mold or yeast?
Mold (hyphae=mycelium)
What % of ‘sick’ people will carry Candida?
40%
What % of infants carry candida? Normal adults?
50% infants….20% adults
Which immune cell opens capillary beds, recruits phagocytic cells, increases epithelial sloughing and increased exudate drainage? What does it do all this with?
T helper 1 cells….by secreting Cytokines
What is the oral manifestation of candidaiasis? What color? Which immune cells get up IN this structure!
Pseudomembrane…COTTAGE CHEESE WHITE in color…PMNs
What are the 4 primary oral candidiasis infections?
- Actue Pseudomembranous 2.Erythematous 3.Chronic Hyperplastic 4.Chronic Mucocutaneous
Which oral candidiasis is associated with ‘denture mouth’?
Chronic Atrophic Erythematous
