L3-Oral Defense Mechs

Question 1

What is unique about the Junctional Epithelium?

Answer 1

It is leaky! not like the attached gingiva!

Question 2

What three things keep fluid in and therefore cause swelling during gingivitis?

Answer 2

Keratin layer, lipid layer, and tight junctions

Question 3

How much more storage of PMNs occurs in the bone marrow then in the blood?

Answer 3

5x more PMNs in marrow then blood

Question 4

What is the PMN half life in blood?

Answer 4

6 hours

Question 5

What are the 6 steps for the PMN to do its thang? What color is the end resulting pus?

Answer 5

1.margination 2.emigration 3.chemotaxis 4.phagocytois 5.local release 6.death…viscous green pus

Question 6

What does CAM stand for?

Answer 6

Cell Adhesion Molecule

Question 7

What is the main antibody in crevicular fluid? Saliva?

Answer 7

Crevicular: IgG like the blood…Saliva: IgA

Question 8

What are the 5 functions of saliva?

Answer 8

1.Dissolve food 2.Buffer 3.Lube 4.Pellicle 5. IgA

Question 9

What is the original source for ‘secreteatory’ component on IgA?

Answer 9

The Fc receptor that hooked IgA into the cell

Question 10

What is sIgA resistant to?

Answer 10

Proteases

Question 11

What is the IgA shape?

Answer 11

Dimeric

Question 12

What are the two Gram - cocci that can metabolize lactic acid?

Answer 12

Neisseria and Veillonella Alcalescens

Question 13

The _________ of the junctional epithelium are poorly differentiated and make little keratin, little hydrophobic granular materials, and are loosely linked to each other. This allows capillary plasma exudate and migrating PMNs to readily pass into the gingival crevice area = ______!

Answer 13

keratinocytes….LEAKY

Question 14

What is PMN half-life in tissue/cells?

Answer 14

1-2 days

Question 15

About 2/3 of blood leukocytes (white blood cells) are _______.

Answer 15

PMN’s

Question 16

How do PMN’s get to the site of infection?

Answer 16

A chemotactic trail

Question 17

The fluid defenses of the oral cavity include both ______ and ________ fluid.

Answer 17

saliva and crevicular

Question 18

What are 2 examples of non specific antimicrobials in saliva?

Answer 18

lysozyme and antimicrobial peptides

Question 19

What are the ___ steps for the production of sIgA’s?

Answer 19

Ag binds to a PMN–>PMN shows T-helper–>T-helper tells B cells to proliferate and make IgA–>IgA w/J-chain get taken into endothelial cell by poly-Ig receptor–>IgA comes out as sIgA with the secretory component attached