19&20-Prevention Flashcards
What are the 4 prevention strategies in the pipeline?
1.STAMP 2.Probiotics 3.Replacement 4.Vaccines
Who is Metchnikoff?
The father of probiotics…the first to say not all bacteria are bad.
What are the 4 probiotic mechanisms?
1.Competative exclusion of pathogens 2.Inhibit growth of pathogens 3.optimize immune response 4.restore normal flora after treatment
What are the 4 ways to inhibit the growth of pathogens?
- Comete for nutrients 2.Release toxic substances 3.Take up space 4. use peroxide or BACTERIOCINS
What can go wrong with an attempt to optimize immunity?
too much immune response can cause collateral damage (sometimes we need to lower immune response)
What are two treatments were we need to restore normal flora?
Antibiotics and dental treatment
What are the four medical research experiments that have shown health improvements using probiotics? rank them from the best results to smallest results..
1.Neonatal Necrotizing Enterocolitis 2.Antibiotic-Associated Diarrhea 3.Clostridium Difficile-Associated Diarrhea 4.Irritable Bowl Syndrome
How much did treating neonatal nectrotizing enterocolitis with probiotics lower the mortality rate?
15%—-5% mortality
What are the 4 oral conditions that have been researched with probiotics?
1.Gingivitis 2.Halitosis 3.Caries 4.Periodontitis
What are the 3 bacterial species used for probiotics?
1.Lactobacillus 2. Streptococcus 3.Bi-fi-do-bacterium
What did that massive study on ranking relevant diseases say about caries, perio disease, and edentualism?
its ranked in the 40’s
Rank these from most effective tx to least…Sealant, fluoride varnish, toothpaste, xylitol
1.sealant 2.xylotol 3.F- varnish 4.toothpaste
What does the acronym STAMP stand for?
Specifically Targeted Anti Microbial Peptide
What are the two main ways to genetically modify S.Mutans to decrease its cariogenicity?
Put the gene for EtOH Dehydrodenase in its DNA so it doesn’t produce acid, and put bactericide in its DNA to kill neighbors.
