L5: Hypothalamus Flashcards
hypothalamus
the most important control area for homeostatic regulation
hypothalamus location
lies under the thalamus on the underside of the brain
pituitary consists of
anterior pituitary and posterior pituitary
pituitary gland sits on
protected pocket of sphenoid bone
pituitary gland is connected to hypothalamus by
infundibulum
anterior pituitary
true endocrine gland of epithelial origin
posterior pituitary
not a gland, but rather an extension of neural components of the hypothalamus
posterior pituitary function
secretion of neurohormones made in the hypothalamus
neurohormones
hormones produced by specialized nerve cells and secreted into the circulation
two nuclei in hypothalamus extending axons to posterior pituitary
supraoptic and paraventricular nuclei
supraoptic nuclei synthesize
vasopressin
paraventricular nuclei synthesize
oxytocin
oxytocin is involved in
stimulation of milk ejection from the mammary glands, contraction of uterine smooth muscle cells until birth during labor
vasopressin (ADH) is involved in
water balance processes in kidneys
vasopressin and oxytocin are stored and released by
posterior pituitary
hypothalamic hormones that regulate anterior pituitary are called
hypophysiotropic or hypothalamic releasing/inhibiting hormones
in anterior pituitary regulation, hypothalamic nuclei send axons to
median eminence
anterior pituitary secretes
six characterized peptide hormones
six anterior hormones
1) Follicle-stimulating hormone (FSH)
2) Luteinizing hormone (LH)
3) Adrenocorticotropic hormone (ACTH)
4) Thyroid Stimulating hormone (TSH)
5) Prolactin
6) Growth hormone
FSH and LH
gonadotropic hormones that stimulate the gonads
ACTH
stimulates the adrenal cortex to secrete cortisol
TSH
induces the thyroid to secrete T3 and T4
Prolactin
controls milk production in the breast
GH
stimulates the liver to secrete the growth promoting hormone, insisting like growth factor
tropic hormones
hormones that stimulate other glands:
FSH, LH, ACTH, TSH
direct hormones
stimulate another part of body directly:
prolactin and growth hormone
ACTH is synthesized in the anterior pituitary from
POMC (pro-opiomelanocortin) protein
POMC also yields
bete-endorphin, opioid that binds to receptors that block pain perception
two inhibitory tropic hormones in hypothalamus
somatostatin (SS) and dopamine (DA)
somatostatin inhibits
growth hormone
dopamine inhibits
prolactin
short-loop feedback
pituitary hormones feed back to decrease hormone secretion by the hypothalamus
long-loop feedback
the last hormone in a pathway feeds back to suppress secretion of hormones by the hypothalamus
hypophysiotropic hormones reach the anterior pituitary via
the portal vessels connecting hypothalamus and anterior pituitary gland
prolactin controls milk __
production
oxytocin controls milk __
ejection