L4 under load 2

Question 1

what are the 4 types of bones cells

Answer 1

osteoprogenitor cells, osteoblast, osteocytes, osteoclast

Question 2

what osteopenia

Answer 2

as we age bone becomes less dense if severe = osteoporosis (bone resorption outpace bone formation) due to lost of calcium and hormonal changes post-menopause

Question 3

what are the zone of the articulate cartilage

Answer 3

superficial zone,
mid zone,
deep zone,
calcified zone

Question 4

what is osteoarthritis

Answer 4

common for of arthritis. It affect all the the tissues of the joints! But primarily articular cartilage .

Question 5

what is a osteophyte

Answer 5

bony lump that grow on the bone around the joint where articular cartilage is damaged

Question 6

describe the stage of osteoarthritis

Answer 6

fibrillation of superficial zone.
cells secrete MMP and collagen lost.
cell divide and form cluster. (attempt to repair)
Loosening of collagen network so proteoglycans not trapped. (cartilage thick and drown in water, it looks good on MRI but very bad)
during later stage blood vessel invade and form subchondral bone.