L3 tissues under load Flashcards
what is the most common type of collagen and what does it make
type 1
bone, tendon, fibrocartilage
what makes type 2 collagen
hyaline cartilage
what makes type 3 collagen
reticular fiber
what makes type 4 collagen
basement membrane
what are the 6 structural levels of collagen
1) synthesis of pro-alpha chain (Gly-X-Y repeats)
2) self-assembly of three pro-alpha chain into triple helix
3) procolagen triple helix followed by secretion of ECM
4) cleavages of propeptide
5) self-assembly into fibril
6) aggregation of collagen fibrils to form a collagen fiber
what is a propeptide and what does it do
it is the a peptid group at help to assemble the three pro-alpha chains into helix
name 3 condition/illness associated with collagen production
scurvy, osteogenesis imperfect, sticker syndrome
what constitute proteoglycans
one or more glycosaminoglycans and a core protein
sight 3 common features of glycosaminoglycans
long, linear carbohydrate polymers.
Negatively charged due to sulphate and uronic groups.
repeating disaccharide
what is the particularity of hyaluronan (HA)
only GAG not sulphated and is everywhere in body. it bind to water and is important for tissue hydration, joint lubricant
what are the propriety of aggrecan
major proteoglycan in cartilage that bind to hyaluronan, hydrophile
what remodel ECM
protease and enzymes
