L4 Red Cells Flashcards

1
Q

describe normal canine erythrocyte morphology

A

biconcave disk

round with central pallor

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2
Q

describe normal feline erythrocyte morphology

A

look kind of like spherocytes. Less central pallor. Sometimes irregular boundaries. Minimal central pallor

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3
Q

describe normal equine erythrocyte morphology

A

no central pallor. “sticky” so often have irregular boundaries (not exactly spherical). Very small!

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4
Q

describe normal alpaca erythrocyte morphology

A

ovoid!

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5
Q

describe normal reptilian erythrocyte morphology

A

nucleated

pink

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6
Q

describe normal avian erythrocyte morphology

A

nucleated

blue

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7
Q

What is rouleaux. In which species is it normal and what does it usually reflect.

A

RBC aggregating in stacks.
Can be normal in cats and horses (naturally sticky).
In other species usually reflects increased protein

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8
Q

What is agglutination. What would we be concerned about if we saw agglutination in a blood smear

A

Grape like clusters of RBC

Concern for immune mediated disease where RBC stick to antigens

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9
Q

What is anisocytosis

A

variable RBC size

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10
Q

What is poikilocytosis

A

variable RBC shape

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11
Q

What is macrocytosis

A

increased average RBC size

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12
Q

What is microcytosis

A

decreased average RBC size

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13
Q

Why might a RBC look pale

A

Low Hb and MCHC

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14
Q

what is hypochromasia

A

pale erythrocytes with increased central pallor

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15
Q

What stain must you use to identify a polychromatophil

A

Wrights Giemsa stain

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16
Q

What stain must you use to identify a reticulocyte

A

New Methylene Blue stain

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17
Q

What are aggregate reticulocytes

A

polychromatophils with many dark reticulin granules

They are released in low numbers in healthy dogs and cats

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18
Q

What are punctate reticulocytes

A

More mature form of polychromatophils with only a few fine reticulin granules.

19
Q

In which circumstance can up to 10% of an animal’s RBC be punctate reticulocytes (in health?)

A

Cats –> RBC have a long maturation time (weeks)

20
Q

What is basophilic stippling? When is it seen in a blood smear?

A

Aggregation of residual RNA in a regenerative response (because are being spat out real quick). Especially seen in ruminants but can seen in any species with a regenerative response

OR, pathological due to lead poisoning or dyserythropoiesis.

21
Q

What makes a Howell jolly body?

A

nuclear remnant left in RBC

22
Q

In which species are Howell jolly bodies seen normally?

A

horses and cats

23
Q

In which pathogeneses might you see increased Howell jolly bodies?

A

post splenectomy
disorders contributing to accelerated erythropoiesis
Hypercortisolaemia
Chemo

24
Q

Why can’t you mistake a Heinz body with a Howell jolly body ??

A

Heinz bodies are only visualised when stained with new methylene blue

25
What is appropriate metarubricytosis
increased numbers of nucleated RBC seen in cases of accelerated aeythropoieiss (regenerative anaemia)
26
What is inappropriate metarubricytosis
increased numbers of nucleated red blood cells without a regenerative response
27
In what circumstances might inappropriate metarubricytosis occur?
``` splenic Dz bone marrow injury lead poisoning inflammation dyserythropoiesis heat stroke myeloproliferative ```
28
What are the overarching causes of anaemia? Are these regenerative?
1. Red cell loss (haemorrhage/ haemolytic) --> REGENERATIVE marrow response 2. Decreased red cell production --> NON REGENERATIVE
29
What're 3x morphological changes you'd see to RBC in a case of IMHA
1. Agglutination 2. Spherocytosis 3. Ghost cells
30
What is a ghost cell?
Just an erythrocyte membrane --> its burst and fucked off
31
why do Heinz bodies form
oxidative damage. | Denatured, precipitated Haemoglobin remains
32
what are eccentrocytes
RBC with haemoglobin (white) condensed to one side due to oxidative injury to the erythrocyte membrane. Often seen in conjunction with Heinz bodies and more frequent in dogs.
33
What're some causes of oxidative damage to RBC in animals
Toxins - garlic/ onions in dogs - zinc in dogs - paracetamol in cats - brassica plants in ruminants - red maple leaves in horse Metabolic Dz - hyperthryroidism - diabetes mellitus - lymphoma
34
What're echinocytes
RBC with lil spikes, evenly spaced | Often an artefact
35
What are some causes of echinocytes
electrolyte depletion strenuous exercise uraemia glomerulonephritis
36
What are codocytes
target cells - increased cell membrane to haemoglobin ratio
37
Under what circumstances might you see codocytes in a blood smear
- regenerative response - liver disease (increased lipid in cell membrane) - lipid metabolism disorder
38
What are acanthocytes
irregular membrane projections
39
What are some possible causes of acanthocytes
splenic, liver Dz Iron deficiency intravascular damage
40
What are schistocytes
cell fragmentos
41
What is a cause of schistocytes
``` DIC Haemangiosarcoma Vasculitis Endocartitis Iron deficiency ```
42
What are blister cells
have a lil white bubble on it. Indicates microvascular angiopathy/ shear injury
43
What are keratocytes
have a lil horn on it | Indicates microvascular angiopathy/ shear injury
44
What do blister cells and keratocytes indicate
DIC, iron deficiency, haemangiosarcoma, liver disease, marrow disease