L4: Iron Flashcards
1
Q
Manner of Poisoning by Iron Toxicity
A
- Iron toxicity typically occur in children, 3-5 tablets may induce significant toxicity according to amount of elemental iron contained in ingested preparation.
2
Q
Toxic Action of Iron Toxicity
A
2
Q
Distribution of Iron
A
Transferrin Carier
- Iron is transported in the blood by transferrin.
- When binding sites on transferrin are saturated, Unbound iron reacts with blood vessels and platelets.
2
Q
Absorbtion of Iron
A
2
Q
Elimination of Iron
A
- There is no significant natural route of elimination other than by Gastrointestinal cell loss & blood loss.
2
Q
1st GI Phase of Iron Toxicity
A
2
Q
CP of Iron Toxicity
A
Severe iron poisoning may proceed in four phases
- 1st Gastrointestinal phase (Gastrointestinal effects)
- 2nd Window phase
- 3rd Multi-organ failure phase
- Late complications phase
3
Q
2nd window Phase of Iron Toxicity
A
3
Q
3rd Multi-Organ Failure phase of Iron Toxicity
A
3
Q
Late Complications phase of Iron Toxicity
A
3
Q
Investigations in Iron Toxicity
A
- Blood Iron Level
- Abdominal X-ray
- Electrolytes, Arterial blood gases & Blood glucose level & Full blood count
- Renal and Liver functions & Coagulation studies.
4
Q
Blood Iron level investigations
A
5
Q
What Might Abdominal X-Ray show in cases of Iron Toxicity?
A
- To identify radio-opaque tablets
- however their absence does not exclude iron overdose.
6
Q
Determination of severity of Iron Toxicity
A
- Clinical Evaluation.
- Blood Iron Level.
- Dose of Ingested Elemental Iron
6
Q
Dose of Ingested elemental Iron
A