L4 GOK

Question 1

neural cell fate are determined in what kind of manner ?

Answer 1

spatio - temporal = where/when they’re born

Question 2

where do intrinsic signals come from ?

Answer 2

precursor cells

Question 3

extrinsic signals from ?

Answer 3

the environment

Question 4

pluripotient means

Answer 4

give rise to 3 germ layers

Question 5

earliest cells in neural tube ?

Answer 5

neural progenitor cells

Question 6

multipotient mean

Answer 6

give rise to specific cells

Question 7

bipotient means

Answer 7

gives rise to two cell types

Question 8

neural stem cells are ?

Answer 8

multi-potent

Question 9

glial progenitor cells are ?

Answer 9

bipotient

Question 10

neurons are specified by a series of ?

Answer 10

fate choices

Question 11

1st fate choice ?

Answer 11

neural or epidermal ectoderm fate

Question 12

neuroprogenitor cells give rise to?

Answer 12

neuorns and glia

neurogenic NPC and gliogenic NPC

Question 13

what determines whether NPC become glia or neurons ?

Answer 13

Neurogenic versus gliogenic signals

Question 14

which comes first neurogenesis or gliogenesis ?

Answer 14

neurogenesis

Question 15

what type of epithelium in neural tube ?

Answer 15

pseudostratified

neuroepithelium

Question 16

where are neuroprogenitors located ?

Answer 16

ventricular layer surface

Question 17

NPC undergo two types of division …

Answer 17

symmeteric - 2 daughter cells
asymmeteric - 1 daughter and post- mitotic cell

post - mitotic - diffrin and delaminates

Question 18

symmetric division gives rise to

Answer 18

new NPC

Question 19

asymmeteric divison gives rise to

Answer 19

cell becomes a neurond that form the mantle layer

mantle layer surrounds ventricular layer
neurons gather

Question 20

what part of the neural tube undergos more cell divisions ?

Answer 20

anterior

Question 21

subregions of forebrain, midbrain hindbrain and sc

Answer 21

forebarin - 6 prosomeres - 3 in tel and 3 in di

midbrain - 1 neuromere

hinbrain - 7-8 rhombomeres

sc - 7 cervical 12 thoracic and 5 lumbar neuromeres

Question 22

what contributes to neuron and glia determination in a spatial manner ?

Answer 22

hox genes

Question 23

dorsal ventral gen expression gives rise to

Answer 23

4 longitudinal domains of neural tube

alar basal roof and floor plates

Question 24

where is Homeobox gene Nkx2.2 expressed?
Msx ?
Gsh1?

Answer 24

ventral part of basal plate
dorsal part of alar plate
lateral level between nkx2.2 & Msx

Question 25

which layer of the cerebral cortex is developed first ?

Answer 25

deep layers

inside out fashion

Question 26

what are ganglion mother cells ?

Answer 26

GMCs are stacks of daughter cells on top of neuroblast s

each GMC produces 2 neurons

Question 27

which is the receptor in delta-notch signalling?

Answer 27

notch

Question 28

one cell activating delta - notch signalling in another causes?

Answer 28

inhibition of proneural genes such as neurogenin and neuro D

Question 29

what process is delta notch signalling involved in ?

Answer 29

lateral inhibition

Question 30

neuroectodermal cells start expressing proneural genes in ?

Answer 30

groups called proneural clusters

Question 31

loss of fuction of notch pathway results in ?

Answer 31

neural development too early

Question 32

loss of proneural genes cause ?

misexpression of proneural genes causes ?

Answer 32

decrease in neural pop

increase in neurons and in epidermis

Question 33

proneural genes encode ?

Answer 33

bHLH basic helix loop helix transcription factors

Question 34

loss of neurogenic function would cause ?

Answer 34

massive increase in neurons at the expense of other cells

Question 35

example of neurogenic genes?

Answer 35

delta and notch