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AN4008 > L3 Andre > Flashcards

L3 Andre Flashcards

1
Q

Neural tube closure starts at what end ?

A

occipital end

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2
Q

Neural tube closure starts day ? ends day ?

A

start - 24

end -26

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3
Q

the neural canal expands to form the ?

A

primary brain vesicles

Prosencephalon, Mesencephalon, Rhombencephalon

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4
Q

Mesecencephalic flexure is

A

a 90 degree ANTERIOR flexure that forms between the prosencephalon and mesencephalon during head folding DAY 25 its completed by WEEK 5

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5
Q

the prosencephalon and rhomboencephalon adopt segmented patterns …

A

Prosomeres p1 to p6 (not well defined),

Rhombomeres r1 to r7

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6
Q

WEEK 5 cervical flexture is located ?

A

junction of hindbrain and sc its and 90 degree ANTERIOR flexure

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7
Q

development of primary brain vesicles leads to deveopment of secondary brain vesicles so as ….

A

Prosencephalon - Telencephalon and diencephalon

Rhombencephalon:

Rhombomeres 1-2 - metencephalon

Rhombomeres 3-7 - myelencephalon

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8
Q

telencephalon gives rise to ?

A

neocortex
paleocortex
corpus striatum

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9
Q

diaencephalon gives rise to ?

A

Thalamus
hypothalamus
epithalamus
infundibulum

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10
Q

mesencephalon

A

midbrain

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11
Q

metencephalon

A

cerebellum and pons

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12
Q

myelencephalon

A

medulla

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13
Q

Ponyine flexure located

A

rostral part of myelencephalon
needed because diffrin growth of dorsal/ventral parts of the brain
folds back = erect position

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14
Q

shortly after neuraltion the neural tube is divided at the

A

ismithic organiser by expression of otx2 (forebrain/midbrain) Gbx (hindbrain/sc)

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15
Q

FGFs excreted by prim streak exert a

A

posterizing influence

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16
Q

anterior ridge secretes ?

A

shh and FGF8

17
Q

This shh FGF8 secreted by the ant ridge causes

A

organising development of the

telencephalon, part of the diencephalon, olfactory area and pituitary gland

18
Q

Zona limitans

A

the border between dorsal and ventral thalamus secretes Shh

19
Q

floorplate secretes mostly ?

A

shh creating a DV gradient

20
Q

what does the ismithic organiser secrete ?

A

wnt1 and fGF8

21
Q

wnt1 and FGF8 induce expression of ?

A

engralied (EN1 and 2) which a homeobox containing genes for development of midbrain and cerebellum

22
Q

hox genes arent expressed in r1 because ?

A

inhibition of RA by FGF8 secreted by ismithic organiser

23
Q

what does CYP26A1 do ?

A

degardes RA prevents it from entering forebrain/midbrain

24
Q

name 4 plates running the length of the neural tube

A

this organisation from caudal end of dicephalon to caudal end of sc

2 basal
2 alar

25
Q

what are the 4 plates of the neural tube connected by ?

A

non- neurgenic regions = floor and roof plate

26
Q

alar plate will form ?

A

dorsal horns and neurons that will synapse with sensory neurons
afferent nuclei - dorsal gray columns

27
Q

basal plate will from?

A

lateral and ventral horns
motor neurons
V0-3 interneurons

28
Q

what causes shh secretion from floor plate ?

A

release of shh from notochord

29
Q

what causes BMP4 and BMP7 expression in roof plate

what else does the roof plate secrete

A

release from dorsal ectoderm

wnt 1

30
Q

roof plate exp of BMPs & wnt1 cause exp of what dorsally ?

A

Pax 3 and 7

31
Q

floor plate exp of shh causes exp of what ventrally ?

A

pax 6

32
Q

Gli3 does ?

what blocks it ?

A

inhibits ventralisation

shh blocks

33
Q

what dorsalining signal do noggin chordin and FST ? block

A

BMP

34
Q

RA is involved in specifying what in the neural tube ?

A

p0 p1 pMN FGF8 with high levels of ventralising FGF8

35
Q

dorsal pallidal region forms ?

A

neocortex and archicortex (hippo c)

36
Q

Ventral subpallial region will form?

lateral and medial ganglionic emmience ?

A

basal ganglia
Lateral ganglionic eminence (corpus striatum)
Medial ganglionic eminence (Globus pallidus)

37
Q

Roof plate sinks into prosencephalic lumen

generating?

A

choroid plexus, and cortical hem

• Generate hippocampus and Ctx

38
Q

RA is responsible for the specification of the which emminence

A

Lateral ganglionic emminence

AN4008 (16 decks)

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