L3 Andre

Question 1

Neural tube closure starts at what end ?

Answer 1

occipital end

Question 2

Neural tube closure starts day ? ends day ?

Answer 2

start - 24

end -26

Question 3

the neural canal expands to form the ?

Answer 3

primary brain vesicles

Prosencephalon, Mesencephalon, Rhombencephalon

Question 4

Mesecencephalic flexure is

Answer 4

a 90 degree ANTERIOR flexure that forms between the prosencephalon and mesencephalon during head folding DAY 25 its completed by WEEK 5

Question 5

the prosencephalon and rhomboencephalon adopt segmented patterns …

Answer 5

Prosomeres p1 to p6 (not well defined),

Rhombomeres r1 to r7

Question 6

WEEK 5 cervical flexture is located ?

Answer 6

junction of hindbrain and sc its and 90 degree ANTERIOR flexure

Question 7

development of primary brain vesicles leads to deveopment of secondary brain vesicles so as ….

Answer 7

Prosencephalon - Telencephalon and diencephalon

Rhombencephalon:

Rhombomeres 1-2 - metencephalon

Rhombomeres 3-7 - myelencephalon

Question 8

telencephalon gives rise to ?

Answer 8

neocortex
paleocortex
corpus striatum

Question 9

diaencephalon gives rise to ?

Answer 9

Thalamus
hypothalamus
epithalamus
infundibulum

Question 10

mesencephalon

Answer 10

midbrain

Question 11

metencephalon

Answer 11

cerebellum and pons

Question 12

myelencephalon

Answer 12

medulla

Question 13

Ponyine flexure located

Answer 13

rostral part of myelencephalon
needed because diffrin growth of dorsal/ventral parts of the brain
folds back = erect position

Question 14

shortly after neuraltion the neural tube is divided at the

Answer 14

ismithic organiser by expression of otx2 (forebrain/midbrain) Gbx (hindbrain/sc)

Question 15

FGFs excreted by prim streak exert a

Answer 15

posterizing influence

Question 16

anterior ridge secretes ?

Answer 16

shh and FGF8

Question 17

This shh FGF8 secreted by the ant ridge causes

Answer 17

organising development of the

telencephalon, part of the diencephalon, olfactory area and pituitary gland

Question 18

Zona limitans

Answer 18

the border between dorsal and ventral thalamus secretes Shh

Question 19

floorplate secretes mostly ?

Answer 19

shh creating a DV gradient

Question 20

what does the ismithic organiser secrete ?

Answer 20

wnt1 and fGF8

Question 21

wnt1 and FGF8 induce expression of ?

Answer 21

engralied (EN1 and 2) which a homeobox containing genes for development of midbrain and cerebellum

Question 22

hox genes arent expressed in r1 because ?

Answer 22

inhibition of RA by FGF8 secreted by ismithic organiser

Question 23

what does CYP26A1 do ?

Answer 23

degardes RA prevents it from entering forebrain/midbrain

Question 24

name 4 plates running the length of the neural tube

Answer 24

this organisation from caudal end of dicephalon to caudal end of sc

2 basal
2 alar

Question 25

what are the 4 plates of the neural tube connected by ?

Answer 25

non- neurgenic regions = floor and roof plate

Question 26

alar plate will form ?

Answer 26

dorsal horns and neurons that will synapse with sensory neurons afferent nuclei - dorsal gray columns

Question 27

basal plate will from?

Answer 27

lateral and ventral horns motor neurons V0-3 interneurons

Question 28

what causes shh secretion from floor plate ?

Answer 28

release of shh from notochord

Question 29

what causes BMP4 and BMP7 expression in roof plate | what else does the roof plate secrete

Answer 29

release from dorsal ectoderm | wnt 1

Question 30

roof plate exp of BMPs & wnt1 cause exp of what dorsally ?

Answer 30

Pax 3 and 7

Question 31

floor plate exp of shh causes exp of what ventrally ?

Answer 31

pax 6

Question 32

Gli3 does ? | what blocks it ?

Answer 32

inhibits ventralisation | shh blocks

Question 33

what dorsalining signal do noggin chordin and FST ? block

Answer 33

BMP

Question 34

RA is involved in specifying what in the neural tube ?

Answer 34

p0 p1 pMN FGF8 with high levels of ventralising FGF8

Question 35

dorsal pallidal region forms ?

Answer 35

neocortex and archicortex (hippo c)

Question 36

Ventral subpallial region will form? | lateral and medial ganglionic emmience ?

Answer 36

basal ganglia Lateral ganglionic eminence (corpus striatum) Medial ganglionic eminence (Globus pallidus)

Question 37

Roof plate sinks into prosencephalic lumen | generating?

Answer 37

choroid plexus, and cortical hem | • Generate hippocampus and Ctx

Question 38

RA is responsible for the specification of the which emminence

Answer 38

Lateral ganglionic emminence