L14 GOK Flashcards
Wnt3a involved in D-V of what ?
retina ganglion cells
motor unit is ?
consists of 1 motor neuron and all the muscle fibres it innervates
each motor has one of 3 types of muscle fibre name muscle fibre types ?
fast twitch , slow twitch , intermediate
NT @ NMJ ?
ACH
nitotinic receptors at postsynapse
what fills synaptic cleft ?
synaptic basal lamina
where are the ACHR located ?
post junctional folds - crest
trough contains NA+ channels
active zone ?
where NT accumulate in vesicles (presynapse)
where do the signals for pre/postsynaptic differentiation localise?
synaptic basal lamina
whats basal lamina?
strong , fibrous permeable matrix for cell attachment
prepatterning ?
clustering of ACHR before axon arrival
once nerve arrives what happens to clusters ?
large clusters form whereaxon innervates while you get disappearance of primitive clusters in non synaptic areas
whats agrin ?
a signal for post-synaptic differentiation secreted by axon
what does agrin do ?
agrin KO ?
causes ACHR clustering
abnormal synapses
choline actyltransferase CHAT KO = ?
synapse formation (LESS ach)
what affect does ACH have on synaptic differentiation
destabilises synapse with no agrin
