L34 Flashcards
during the absorptive phase the liver can either produce FAs from glucose and amino acids or it can consume FAs and channel them into the ?
krebs cycle or ketogenesis
when is the krebs cycle vs ketogenesis used
low levels of Malonyl coA stimulates ketogenesis
during what phases is malonyl-CoA low and why
during post-abs and prolonged deficiency
b/c glucagon inhibits glycolysis
during the absorptive phase when _____ is high, Malonyl-CoA suppresses ______
insulin
CPT-1
FAs are released from adipose tissue and transported into the mitochondria by ?
CPT-1
once in the mitochondria, what happens to FAs
beta oxidation and ketone body synthesis
explain the normal process of fat metabolism during prolonged E deficiency
NEFAs from adipose tissue get transported into hepatocytes
inside hepatocytes, NEFAs get esterified to TGs and packed into VLDLs which are able to enter circulation
what diseases are associated w/ hepatic lipidosis in cats
- old age
- obesity
- DM
- pancreatitis
- diabetic ketoacidosis
- IBS
- hepataits
- cancer
what is hepatic lipidosis
(fatty liver disease)
occurs when cat stopes eating for a while, causing the body to break down stored fat for E, the liver can’t handle emulsifying large amounts of fat so it becomes overwhelmed and then its functioning is compromised
overwhelming hepatocyte capactiy (hepatocytes cant handle a large amount of NEFAs), causes damage to hepatocytes –> hypoxia, hepatotoxins increase and damage liver cells
an accumulation of triglycerides leads to fatty ____
liver
symptoms of hepatic lipidosis
anorexia, obesity, icterus, liver enlargement, V+
what is the treatment for hepatic lipidosis in cats
- high protein diet
- feeding tube and diazepam
how do ruminants maintain glucose homeostasis?
convert glucose to glycerol and acetate and beta hydroxybutyrate into FAs
ketone bodies supply E (they are in a constant state of gluconeogenesis)
during starvation how is serum electrolyte balance maintained
shift of intracellular ions (K, P, Mg) to the extracellular space, leading to a depletion of electrolytes
what is the order in which E stores are depleated
carbohydrates
fat
protein
