L1: development of reproductive system Flashcards
sex cords form in response to …..
PGCs
primordial germ cells
once the genital ridge develops, what two ducts form
Mesonephric (Wolffian) and Paramesonephric (Mullerian) ducts
when PGCs reach the genital ridge, they establish as _______, precursors to gonads
Gonocytes
what chromosomes are necessary for the formation of testes
SRY (+XY)
A lack of SRY and TDF results in the formation of…
Oogonia (XX)
- granulosa cells
- thecal cells
during testicular development, cord cells and mesonephric cells become ____ cells
Sertoli
during male gonadal development, interstitial cells become ______ cells
Leydig
(source of testosterone)
in ovary development, cord cells become _____ cells
Granulosa
Leydig cells produce….
testosterone
Sertoli cells produce…
Anti-Mullerian Hormone (AMH)
- inhibits the development of Mullerian ducts
____________ (hint: hormone) targets the Wolffian ducts to become what 3 things
testosterone
- Epididymis
- Vas deferens
- seminal vesicles
hormone needed for theformation of external male genitalia(scrotum, penis, glans, prostate)
Dihydrotestosterone (DHT)
________ converts testosterone to dihydrotestosterone
5α reductase
the female fallopian tubes, uterus and vagina form from what
Mullerian ducts
in females, as the Mullerian ducts develop into female reproductive genitalia, ______ ducts regress
Wolffian
The absence of what 3 things allows for female genitalia to appear
No testosterone (Wolffian ducts regress)
No DHT
No AMH
what is the role of the HPG axis in sexual development, puberty and maturation
functions during fetal life to promote the development of gonads
HPG is signaled by the hypothalamus to initiate puberty
testes migrate through the ____ and _____ to reside in the scrotum
Body wall and Inguinal canal
what are the 3 phases of testicular descent
Transabdominal phase
1. Descent from retroperitoneal position
2. growth of gubernaculum *IGF3
Inguinal-scrotal phase
3. shrinkage of gubernaculum back to scrotum and through the inguinal canal *testosterone
T/F: cryptorchid testes can occur in males of any species
T
the transabdominal phase of testicular descent is dependent on what molecule
IGF3
the inguinal-scrotal phase of testicular descent is dependent on what
testosterone
