L27 Drugs that induce sleep

Question 1

orexin antagonist

Answer 1

wake NT

onset and maintenance of sleep

Question 2

Benzodiazpines

Answer 2

Potentiate the action of GABA at the ionotropic GABA receptor
-targets GABA
-safer than barbiturates
onset of sleep

Question 3

Z drugs

non benzodiazpines

Answer 3

potentiate the action of GABA at the ionotropic GABA receptor
targets GABA

Question 4

Barbiturates

Answer 4

used less now bc of tolerance, physical dependence and withdrawal symptoms
(replaced by benzo)
-Decreased neuronal activity
+ve allosteric regulator of GABA2 receptor

Question 5

Melatonin receptor agonist

Answer 5

affinity for melatonin MT1 and MT2 receptors
Does not bind to GABA receptors
long term use
onset of sleep

Question 6

Histamine receptor H1 antagonists

Answer 6

a trycyclic antidepressant with h1 antagonism
Maintenance of sleep
Used for depression and insomnia