L22 Antidepressants

Question 1

1 Tricyclic Antidepressant Drug

Answer 1

Amitriptyline

Question 2

1 SSRI drug

Selective Serotonin Reuptake Inhibitors

Answer 2

Fluoxetine

Question 3

Example of Monoamine Oxidase Inhibitors

MAOI

Answer 3

Moclobemide

Question 4

What do MAOIs do?

Answer 4

Inhibit MAO from breaking down NA, 5HT and dopamine
Thus increase the levels of
-serotonin, NA and dopamine

Question 5

What does Moclobemide do?

And Side effects

Answer 5

MAOI
Reversible inhibitor of MAOI- RIMAs
-MAO is inhibited thus tyramine is no longer broken down
-Build up of tyramine -> increase levels of NA
-> hypertension

Side effects
dizziness, nausea, insomnia
-less likely to cause cheese reaction

Question 6

1 Bipolar Affective Disorder drug

Answer 6

Lithium carbonate

Question 7

Lithium carbonate

Side efefcts

Answer 7

Main mood stabilising drug
Regular blood test due to low therapeutic index
Very toxic
Renal- kidney issues, thyroid, neurological

Question 8

What do TCA antagonise?

Tricylic antidepressants

Answer 8

Blocks reuptake of NA -> increase NA
Blocks alpha 1 adrenoceptors, muscarinic receptors-> atropine like effects-> anti SLUD
Blocks Histamine 1-> sedation and Histamine 2