L18-19 Drug discovery

Question 1

Imatinib

Answer 1

antitumor drug

targets tyrosine kinase

Question 2

Zanamivir

Answer 2

anti influenza drug
targets neuraminidase
neuraminidase inhibitor- blocks the function of viral neuraminidases of the influenza virus- preventing viral reproduction by budding from the host cell

Question 3

Cimetidine

Answer 3

treats gastric ulcers
H2 receptor
antagonist that inhibits stomach acid production

Question 4

Steps of design

Answer 4

1) disease
2) target selection
3) Discovering a lead
4) Optimising leads
5) Preclinical development and toxicology
6) clinical trials
7) approval