L16 Asthma

Question 1

Salbutamol

Terbutaline

Answer 1

SABA
Short acting beta 2 adrenonceptor agoinst
Bronchodilation, relievers

Question 2

Salmeterol

Formoterol

Answer 2

LABA
Long acting beta 2 adrenoceptor agonists
Controllers

used in combination with inhaled GCs, glucocorticoids

Question 3

Zarfirlukast

Monotelukast

Answer 3

Cysteinyl Leukotriene receptor antagonists
Bronchodilators
orally active
used in combination with GCS/beta 2 agonist

Question 4

Neodocromil sodium

Disodium cromoglycate DSCG

Answer 4

Non steroidal anti-allergic drugs NSAAD
Administered by inhalation
Reduce mediator release
Modest anti-inflammatory activity

Question 5

inhaled:
- Budesonide
- Fluticasone Propionate

oral: Prenisolone

Answer 5

Glucocortcoids used to treat asthma

Question 6

Mechanism of beta 2 adrenoceptor agonists

Answer 6

beta 2-> 2ndary msger Gs -> Adenylate cyclase-> ATP -> cAMP-> PKA -> Ca pumps phosphorylated reduced cytoplasmic Ca

MLCK phosphoylated-less activity

Less Ca-> less activity of MLCk-> less shortening-> airways dilate

Question 7

Mechanism of glucocorticoids

Answer 7

• Diffuses across membrane
• Binds cytosolic receptor (GR)
GCs chaperone- masks a site of the GCs receptor that enables it to move into the nucleus
− With masking the receptor remains in the cytoplasm
When the steroid binds to cytosolic receptor-> chaperone dissociates
• Translocate to nucleus
• Repress some and activate other genes
-> activates genes