L&M Chapter 3 Flashcards
What does blood do in brain?
Remove toxic waste products in neural tissue
Oxygen and glucose supply
What is a stroke?
Cerebrovascular accident (CVA) Clinical signs of focal disturbance of cerebral function with prob vascular origin > 24 hour period
What are the two types of stroke?
Hemorrhagic (bleeding from vessel) - 20%
Occlusive (blockage of vessel) - 80%
What are two types of haemorrhagic stroke?
Subarachnoid (50%)
Intracerebral (50%)
Describe intracerebral stroke
Blood escapes into surrounding tissue, destroys it
Localised
What percentage of haemorrhagic strokes are subarachnoid?
Approx 50%
What percentage of strokes are occlusive?
Approx 80% all strokes
Much lower mortality rate than haemorrhagic
What are two main types of occlusive stroke?
- Cerebral Thrombosis - narrowing of vessel, caused by build up of plaque (aatherosclerosis)
- Cerebral Embolism - plaque comes from elsewhere in body, gets stuck in narrower vessels in brain.
What impacts on size of infarction (in occlusive stroke)
- location of occlusion, and extent of collateral circulation
- how big blood vessel is
Describe memory function after ischaemic strokes?
- severe amnesic results if happens in anterior choroidal arteries (MTLs) or posterior cerebral arteries (thalamus)
- less severe if happens in anterior cerebral arteries (medial frontal lobes, mammillary bodies, fornix, anterior Cingulate cortex) or middle cerebral arteries (lateral frontal and temporal lobes)
What is effect of stroke size on outcome?
Localised - less effect
Generalised - much greater cognitive disfunction
What is recovery period after stroke
Most significant repaid 0-3 months (daily - weekly improvement)
Continued improvement 3-6 months (monthly improvement)
Rare improvement after 12 months
What is vascular dementia?
Second most common dementia, after AD
Caused by multiple strokes, lesions over time
What are some symptoms of frontal lobe stroke?
Inappropriate comments, confabulation Lack of anxiety or concern about state Lack of planning or organisation Impaired unassociated word pairings, same level as associated Verbal recall improved with recognition Less loss of visual memory
Describe impairment of memory in stroke
Can occur in isolation due to lesioning of structures in primary memory structures
Can occur in conjunction with impairment of other domains, and may be less significant than other dysfunctions
What are three types of head injury?
Penetrating (causes localised deficit dependent on location)
Crushing (most damage to base of brain)
Closed head injury (by far most common)
What causes damage in CHI?
- movement of soft cerebral tissue against hard bony skull
- Stretching of brain from its stem
Describe diffuse axonal injury in CHI
- stretching and shearing of cortical fibres (stretched from ‘anchor’ in brain stem)
- widespread damage
- reticular formation (at base of brain - responsible for attentiveness and arousal - hence common loss of consciousness)
- arteries and veins may be torn
- coup and contracoup injuries
What are coup injuries in CHI?
Contusions (haemorrhagic lesions) that occur at point of impact where brain hits skull
What are contre-coup injuries in CHI?
Contusions (haemorrhagic lesions) that occur on crests of gyri of cerebral cortex, usually on outside of cortex (can be sub cortical). Opp side to impact.