Effects Of Drugs On Neurotransmitters Flashcards
What does reserpine do?
Prevents storage of MOAs in vesicles
Antagonist
What does L-dopa do?
Precursor to dopamine
Agonist
What does PCPA do?
Inactivates synthetic enzyme, inhibiting synthesis of serotonin
Antagonist
What does black widow spider venom do?
Stimulates production of ACh
Agonist
What does botulinum toxin do?
Inhibits release of ACh
Antagonist
What do nicotine and muscarine do?
Stimulate postsynaptic receptors
Agonists
What do curare and atropine do?
Block postsynaptic receptors to ACh
Antagonist
What does apomorphine do?
Stimulates autoreceptors in presynaptic terminal, inhibits release of dopamine
Antagonist
What does cocaine do?
Blocks reuptake of dopamine
Agonist
What does physostigmine do?
Inactivates AChE
Agonist
What does botulin toxin interact with?
ACh
Antagonist
What does black widow spider toxin interact with?
ACh
Agonist
What does cocaine interact with?
Dopamine
Agonist (inhibit reuptake)
What do curare and atropine interact with?
ACh
Antagonist (block post synaptic receptors)
What drug does reserpine interact with?
MOAs
Antagonist (prevent storage in vesicles)
What does L-dopa interact with?
Dopamine
Agonist (precursor)
What does PCPA interact with?
Serotonin
Antagonist (prevents synthesis)
What does apomorphine interact with?
Dopamine
Antagonist - stimulates presynaptic autoreceptors
What is role of dopamine?
nigrostriatial [substanti nigra - striatum] - movement
mesolimbic [ventral tegmental - limbic, incl nucleus accumbens] - reinforcement
mesocortical [ventral tegmental - frontal cortex] - short term memories, planning, problem solving
What is role of acetylcholine?
Dorsolateral pons - REM sleep
Basal forebrain - learning
Medial septum - control electrical rhythm of hippocampus - memories
What is role of norepinephrine?
Vigilance, readiness to act
What is role of histamine?
Wakefulness
What is role of serotonin?
Regulation of mood; eating, sleep, regulation of pain
What is MDMA?
Ecstasy
agonist for norepeniphrene and serotonin
What drug inhibits synthesis of dopamine?
AMPT
What does deprynyl do to MAO in cell?
Inhibits MAO, therefore acts as agonist
What does chlorpromazine do?
Blocks post synaptic receptor for dopamine - antagonist
How does amount of apomorphine change the impact on dopamine?
Low amounts inhibit presynaptic receptor [antagonist]
High amounts activate postsynaptic receptor [agonist]
What do amphetamines do to norepeniphrine?
Stimulate release and block reuptake [agonist]
What does fenfluramine do to seratonin?
releases seratonin
What does fluoxetine - prozac do to seratonin?
Blocks reuptake [agonist]
