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Bio psych > Effects Of Drugs On Neurotransmitters > Flashcards

Effects Of Drugs On Neurotransmitters Flashcards

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0
Q

What does reserpine do?

A

Prevents storage of MOAs in vesicles

Antagonist

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1
Q

What does L-dopa do?

A

Precursor to dopamine

Agonist

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2
Q

What does PCPA do?

A

Inactivates synthetic enzyme, inhibiting synthesis of serotonin
Antagonist

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3
Q

What does black widow spider venom do?

A

Stimulates production of ACh

Agonist

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4
Q

What does botulinum toxin do?

A

Inhibits release of ACh

Antagonist

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5
Q

What do nicotine and muscarine do?

A

Stimulate postsynaptic receptors

Agonists

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6
Q

What do curare and atropine do?

A

Block postsynaptic receptors to ACh

Antagonist

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7
Q

What does apomorphine do?

A

Stimulates autoreceptors in presynaptic terminal, inhibits release of dopamine
Antagonist

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8
Q

What does cocaine do?

A

Blocks reuptake of dopamine

Agonist

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9
Q

What does physostigmine do?

A

Inactivates AChE

Agonist

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10
Q

What does botulin toxin interact with?

A

ACh

Antagonist

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11
Q

What does black widow spider toxin interact with?

A

ACh

Agonist

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12
Q

What does cocaine interact with?

A

Dopamine

Agonist (inhibit reuptake)

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13
Q

What do curare and atropine interact with?

A

ACh

Antagonist (block post synaptic receptors)

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14
Q

What drug does reserpine interact with?

A

MOAs

Antagonist (prevent storage in vesicles)

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15
Q

What does L-dopa interact with?

A

Dopamine

Agonist (precursor)

16
Q

What does PCPA interact with?

A

Serotonin

Antagonist (prevents synthesis)

17
Q

What does apomorphine interact with?

A

Dopamine

Antagonist - stimulates presynaptic autoreceptors

18
Q

What is role of dopamine?

A

nigrostriatial [substanti nigra - striatum] - movement
mesolimbic [ventral tegmental - limbic, incl nucleus accumbens] - reinforcement
mesocortical [ventral tegmental - frontal cortex] - short term memories, planning, problem solving

19
Q

What is role of acetylcholine?

A

Dorsolateral pons - REM sleep
Basal forebrain - learning
Medial septum - control electrical rhythm of hippocampus - memories

20
Q

What is role of norepinephrine?

A

Vigilance, readiness to act

21
Q

What is role of histamine?

A

Wakefulness

22
Q

What is role of serotonin?

A

Regulation of mood; eating, sleep, regulation of pain

23
Q

What is MDMA?

A

Ecstasy

agonist for norepeniphrene and serotonin

24
Q

What drug inhibits synthesis of dopamine?

A

AMPT

25
Q

What does deprynyl do to MAO in cell?

A

Inhibits MAO, therefore acts as agonist

26
Q

What does chlorpromazine do?

A

Blocks post synaptic receptor for dopamine - antagonist

27
Q

How does amount of apomorphine change the impact on dopamine?

A

Low amounts inhibit presynaptic receptor [antagonist]

High amounts activate postsynaptic receptor [agonist]

28
Q

What do amphetamines do to norepeniphrine?

A

Stimulate release and block reuptake [agonist]

29
Q

What does fenfluramine do to seratonin?

A

releases seratonin

30
Q

What does fluoxetine - prozac do to seratonin?

A

Blocks reuptake [agonist]

Bio psych (14 decks)

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