L-37

Question 1

What is severe combined immunodeficiency?

Answer 1

X chromosome linked disease that causes patients to lack functional T and B cells

Question 2

What group is SCID most common in?

Answer 2

XY males

Question 3

What cells are targeted and killed by HIV?

Answer 3

CD4-T cells

Question 4

What does HIV infection impact on in the immune system? And therefor what is the effect?

Answer 4

CD4 T helper cells, lack of Immunity to microbes and to cancer ( can also effect macrophages, monocytes, and dendritic cells)

Question 5

What normally prevents autoimmune disease?

Answer 5

Host mechanisms of immune tolerance

Question 6

What developes immune tolerance?

Answer 6

Thymus acts to delete auto reactive T cells

Question 7

What is rheumatoid arthritis?

Answer 7

An autoimmune disorder that primarily affects joints

Question 8

Around what percent of the population is affected by rheumatoid arthritis?

Answer 8

1%

Question 9

What autoimmune response cause type 1 diabetes?

Answer 9

Attack of insulin producing beta cells

Question 10

What is the name for antigens that trigger allergic reactions?

Answer 10

Allergens

Question 11

What are normal allergens?

Answer 11

Non toxic plant, animal, and food materials

Question 12

What is the effector response to allergens? ( peanut)

Answer 12

• DC present peptides from peanut proteins to helper T cells
• Primed helper T cells activate B cells to secrete IgE
• Secreted IgE binds to mast cell receptor (FcR)
• binding of peanut proteins to FcR on mast cells triggers mast cell degranulation and release of histamine and other inflammatory mediators

Question 13

What is the most common cause of food allergies in children?

Answer 13

Peanuts

Question 14

What percent of the people in the US have a peanut allergy?

Answer 14

2%

Question 15

For what percent of people are peanut allergies lifelong?

Answer 15

80%