L-38 Flashcards
Where can viral proteins enter the dendritic cell?
- phagolysosome
- Cytosol
Where is the phagolysosomal antigen loaded and what for?
- loaded onto MHC-II for CD4 helper T cell activation/ stimulation
Where is the cytosolic viral antigen loaded and what for?
- loaded onto MHC-I for CD8 T cell activation/ stimulation
What is clonal selection/expansion?
Selective expansion of lymphocytes that interact with antigen
Where can bacterial antigens enter the DC
Phagolysosome
Where is the bacterial phagosomal antigen loaded and why?
- phagosomal antigen will be loaded onto MHC-II for CD4 T cell stimulation
What do activated CD4 helper T cells do?
-stimulate B cells to make antibody
The predominance of what classes of antibody characterise the secondary immune response?
IgG, IgA, IgE
What binds native antigens?
Antibodies
What does native antigen mean?
Antigen not processed to peptide
What are adjuvants?
Immune stimulants added to vaccines that enhance the activation of antigen presenting cells
What type of vaccines usually require adjuvants?
sub-unit vaccines
What is an example of a vaccine that is intrinsically adjuvinated?
MRNA SARS -2 Vaccine
What part of the mRNA SARS-2 vaccine is immunostimuatory?
Lipid encapsulated mRNA
